公开(公告)号：US20230047209A1

公开(公告)日：2023-02-16

申请号：US17366923

申请日：2021-07-02

Applicant: Genentech, Inc.

Inventor： Marie-Gabrielle Braun ,  Georgette Castanedo ,  Paul Gibbons ,  Joachim Rudolph ,  William Vernier ,  Ramsay Beveridge ,  Yao Wu ,  Guosheng Wu

IPC: C07D471/04 ,  C07D475/00

Abstract: Described herein are pyrido-pyrimidinone and pteridinone compounds or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods treating cancer, alone and in combination with other therapeutic agents.

公开(公告)号：US20220249487A1

公开(公告)日：2022-08-11

申请号：US17643623

申请日：2021-12-10

Applicant: Genentech, Inc.

Inventor： Marie-Gabrielle Braun ,  Georgette Castanedo ,  Paul Gibbons ,  Joachim Rudolph ,  Yao Wu ,  Guosheng Wu

IPC: A61K31/517 ,  C07D401/12 ,  C07D239/84 ,  C07D401/04 ,  C07D401/14 ,  A61K31/573 ,  A61K38/07 ,  A61K31/69 ,  A61K31/454 ,  A61K39/395 ,  C07D405/14

Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof useful in the treatment of IRE1-related diseases and disorders described herein.

公开(公告)号：US20220204498A1

公开(公告)日：2022-06-30

申请号：US17404568

申请日：2021-08-17

Applicant: Genentech, Inc.

Inventor： Marie-Gabrielle Braun ,  Joachim Rudolph ,  Yao Wu ,  Guosheng Wu

IPC: C07D471/04

Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof useful in the treatment of IRE1-related diseases and disorders described herein.