公开(公告)号：US20250002609A1

公开(公告)日：2025-01-02

申请号：US18740409

申请日：2024-06-11

Applicant: Genentech, Inc.

Inventor： Cecilia P.C. CHIU ,  Hilda Y. HERNANDEZ-BARRY ,  David B. IAEA ,  Moulay Hicham ALAOUI-ISMAILI ,  James T. KOERBER ,  Wei Yu LIN ,  Kelly LOYET ,  Yonglian SUN ,  Benjamin T. WALTERS ,  Jawahar SUDHAMSU

IPC: C07K16/40 ,  A61K47/68

Abstract: The invention provides anti-KLK5 antibodies and methods of using the same.

公开(公告)号：US20170137518A1

公开(公告)日：2017-05-18

申请号：US15397399

申请日：2017-01-03

Applicant: Genentech, Inc.

Inventor： Ali ZARRIN ,  Yonglian SUN

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K16/28 ,  C07K2317/76 ,  G01N33/566

Abstract: Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed. Also disclosed are therapeutic uses of reagents in treating inflammation-related disorders.

公开(公告)号：US20220099677A1

公开(公告)日：2022-03-31

申请号：US17469533

申请日：2021-09-08

Applicant: GENENTECH, INC.

Inventor： Vinita GUPTA ,  Ann Therese BRADY ,  James Thomas KOERBER ,  Xiangdan WANG ,  Minh Michael Nhu PHAN ,  Yonglian SUN

IPC: G01N33/574

Abstract: The present disclosure provides assays for the detection and/or quantification of membrane-associated proteins, e.g., circulating CD20 (cCD20), incorporating an extracellular vesicle-based calibrator comprising the membrane-associated tumor antigen as well as the use of such assays in the detection and treatment of hyperproliferative disorders.

公开(公告)号：US20190276532A1

公开(公告)日：2019-09-12

申请号：US16181246

申请日：2018-11-05

Applicant: Genentech, Inc.

Inventor： Ali ZARRIN ,  Yonglian SUN

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/566

Abstract: Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed. Also disclosed are therapeutic uses of reagents in treating inflammation-related disorders.

公开(公告)号：US20150203575A1

公开(公告)日：2015-07-23

申请号：US14598870

申请日：2015-01-16

Applicant: Genentech, Inc.

Inventor： Ali ZARRIN ,  Yonglian SUN

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K16/28 ,  C07K2317/76 ,  G01N33/566

Abstract: Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed. Also disclosed are therapeutic uses of reagents in treating inflammation-related disorders.

Abstract translation: 本文描述的是新的受体 - 配体相互作用和可以修饰和/或阻断相互作用的试剂。 公开了用于调节与其与新受体的相互作用相关的配体活性的方法，用途，试剂和试剂盒。 还公开了试剂治疗炎症相关疾病的治疗用途。