公开(公告)号：US20230341379A1

公开(公告)日：2023-10-26

申请号：US18188665

申请日：2023-03-23

Applicant: Genentech Inc.

Inventor： Katherine Kozak ,  Josefa dela Cruz Chuh

IPC: G01N33/50 ,  G01N33/58

CPC classification number: G01N33/505 ,  G01N33/5011 ,  G01N33/5038 ,  G01N33/582

Abstract: The present disclosure provides methods and systems for high throughput assays for testing immune cell engager molecules and potential immune cell engager molecules. In some embodiments, multiple parameters, for example, in connection with engagement of tumor cells by immune cells such as T cells and in connection with tumor cell death, may be analyzed from the same samples in the assays, and, in some cases, may be analyzed simultaneously. In some embodiments, the methods and systems allow for determining the kinetics of various parameters.