公开(公告)号：US20230048743A1

公开(公告)日：2023-02-16

申请号：US17811316

申请日：2022-07-08

Applicant: Genentech Inc.

Inventor： Elizabeth Sara Hecht ,  Shrenik Chetan Mehta ,  Wendy Noel Sandoval ,  Sreedhara Alavattam ,  Nathaniel Robert Tzizik-Swanson

IPC: C07K16/40 ,  C12N15/85

Abstract: The present application relates to recombinant antibodies that are engineered to alter interactions between the antibodies and one or more endogenous lipases of a host cell used to produce the antibodies. In some cases, the antibodies are mutated in the heavy chain constant region, such as at CH1, CH2, and/or CH3. In other cases, the antibodies are mutated to alter their glycosylation profile.