公开(公告)号：US20200080047A1

公开(公告)日：2020-03-12

申请号：US16128121

申请日：2018-09-11

Applicant: General Electric Company

Inventor： Matthew Jeremiah Misner ,  Rachel Marie Gettings ,  Christine Angela Morton ,  Erik Leeming Kvam ,  Jason William Castle ,  Anindya Kanti De ,  Jared Timothy Hale ,  Craig Patrick Galligan ,  Vincent Francis Pizzi

IPC: C12M1/00 ,  C12M1/32 ,  B01D17/02 ,  B01D21/02 ,  B01D21/00 ,  B01L3/00 ,  B01D21/24 ,  G01N30/00

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

公开(公告)号：US10948400B1

公开(公告)日：2021-03-16

申请号：US16573721

申请日：2019-09-17

Applicant: General Electric Company

Inventor： Radislav Alexandrovich Potyrailo ,  Jared Timothy Hale ,  Christian M. Heller

IPC: G01J3/44 ,  G01N21/05 ,  G01N21/31 ,  G01N21/47 ,  G01N21/01

Abstract: A method of forming an optical transmission flow cell that includes forming a fluid pathway cavity though a housing, and forming an optical pathway cavity through the housing and through the fluid pathway cavity, the optical pathway cavity configured to receive an optical fiber to emit light through the fluid pathway cavity. Material is added at a transition between the optical pathway cavity and fluid pathway cavity to form a surface at the transition configured to prevent formation of air pockets within fluid in the optical pathway cavity.

公开(公告)号：US20210080381A1

公开(公告)日：2021-03-18

申请号：US16573721

申请日：2019-09-17

Applicant: General Electric Company

Inventor： Radislav Alexandrovich Potyrailo ,  Jared Timothy Hale ,  Christian M. Heller

IPC: G01N21/05 ,  G01N21/47 ,  G01N21/31

Abstract: A method of forming an optical transmission flow cell that includes forming a fluid pathway cavity though a housing, and forming an optical pathway cavity through the housing and through the fluid pathway cavity, the optical pathway cavity configured to receive an optical fiber to emit light through the fluid pathway cavity. Material is added at a transition between the optical pathway cavity and fluid pathway cavity to form a surface at the transition configured to prevent formation of air pockets within fluid in the optical pathway cavity.