公开(公告)号：US09778263B2

公开(公告)日：2017-10-03

申请号：US14079347

申请日：2013-11-13

Applicant: General Electric Company

Inventor： Srabani Bhaumik ,  Michael John Gerdes ,  Zhengyu Pang ,  Fiona Ginty ,  Christopher James Sevinsky ,  Qing Li ,  Alberto Santamaria-Pang ,  Yunxia Sui ,  Keyur Hemantkumar Desai

IPC: G01N33/574 ,  G01N33/569 ,  G01N33/543 ,  G06T7/00 ,  G06K9/00 ,  G01N1/30

CPC classification number: G01N33/57492 ,  G01N1/30 ,  G01N33/54393 ,  G01N33/56972 ,  G01N33/56977 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/30024

Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a distribution, location, and type of a plurality of the characterized cells.

公开(公告)号：US20150133321A1

公开(公告)日：2015-05-14

申请号：US14079347

申请日：2013-11-13

Applicant: General Electric Company

Inventor： Srabani Bhaumik ,  Michael John Gerdes ,  Zhengyu Pang ,  Fiona Ginty ,  Christopher James Sevinsky, JR. ,  Qing Li ,  Alberto Santamaria-Pang ,  Yunxia Sui ,  Keyur Hemantkumar Desai

IPC: G01N33/574

CPC classification number: G01N33/57492 ,  G01N1/30 ,  G01N33/54393 ,  G01N33/56972 ,  G01N33/56977 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/30024

Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a distribution, location, and type of a plurality of the characterized cells.

Abstract translation: 本公开涉及生物样品的表征。 举例来说，可以将生物样品与样品中靶标特异性的多种探针接触，例如用于免疫标记和分割探针的探针。 可以使用样本的获取图像数据将图像分割成上皮和基质区域，以基于探针的结合来表征样品中的各个细胞。 此外，生物样品可以由多个表征的细胞的分布，位置和类型来表征。