公开(公告)号：US20160333327A1

公开(公告)日：2016-11-17

申请号：US15151364

申请日：2016-05-10

Applicant: Genia Technologies, Inc.

Inventor： Aruna AYER ,  Cleoma ARNOLD ,  Charles Wayan SCHWAB ,  Eileen THAI ,  Ilya LEDERMAN ,  Colin Alexander MCGAW ,  Tyler O'Brien SHULTZ

IPC: C12N9/12

Abstract: Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, 1295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.

Abstract translation: 本文描述的是具有至少一个选自H223，N224，Y225，H227,1295，Y342，T343，I357，S360，L361，I363，S365，S366，Y367，P368，D417，E475，Y476， F478，K518，H527，T529，M531，N535，G539，P542，N545，Q546，A547，L549，I550，N552，G553，F558，A596，G603，A610，V615，Y622，C623，D624，I628，Y629， R632，N635，M641，A643，I644，T647，I648，T651，I652，K655，W656，D657，V658，H660，F662，L690及其组合。