公开(公告)号：US20060211048A1

公开(公告)日：2006-09-21

申请号：US11437969

申请日：2006-05-19

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N33/6893 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

公开(公告)号：US20050287599A1

公开(公告)日：2005-12-29

申请号：US11144402

申请日：2005-06-03

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G01N33/68 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53

CPC分类号： G01N33/6893

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：US06703366B2

公开(公告)日：2004-03-09

申请号：US09846343

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： A61K3800

CPC分类号： G01N33/6893 ,  G01N2800/042 ,  G01N2800/324 ,  Y10T436/24 ,  Y10T436/25

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：US06617308B2

公开(公告)日：2003-09-09

申请号：US09846345

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： A61K3800

CPC分类号： G01N33/6893 ,  G01N2800/042 ,  Y10T436/24 ,  Y10T436/25

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

公开(公告)号：US07314717B2

公开(公告)日：2008-01-01

申请号：US09845738

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/6893 ,  Y10T436/13 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的存在或不存在至少一种疾病状态的能力。

公开(公告)号：US20060024671A1

公开(公告)日：2006-02-02

申请号：US11241443

申请日：2005-09-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： C12Q1/70

CPC分类号： G01N33/6893 ,  Y10T436/13 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：US06756476B2

公开(公告)日：2004-06-29

申请号：US09846344

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： C07K700

CPC分类号： G01N33/6893 ,  G01N2800/042 ,  Y10T436/24 ,  Y10T436/25

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：US06627607B2

公开(公告)日：2003-09-30

申请号：US09846351

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： A61K3800

CPC分类号： G01N33/6893 ,  Y10T436/24 ,  Y10T436/25

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：US07294688B2

公开(公告)日：2007-11-13

申请号：US09845715

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： A51K38/10

CPC分类号： G01N33/6893

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的存在或不存在至少一种疾病状态的能力。

公开(公告)号：US07087435B2

公开(公告)日：2006-08-08

申请号：US09846328

申请日：2001-04-30

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G06F19/00 ,  G01N33/48

CPC分类号： G01N33/6893 ,  Y10S436/811 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的存在或不存在至少一种疾病状态的能力。