公开(公告)号：US20080044384A1

公开(公告)日：2008-02-21

申请号：US11571081

申请日：2005-06-24

申请人： George Kemble ,  Harry Greenberg ,  Gregory Duke

发明人： George Kemble ,  Harry Greenberg ,  Gregory Duke

IPC分类号： A61K35/76 ,  A61P43/00 ,  C12N7/01 ,  C12N7/04

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  C12N2710/16134 ,  C12N2710/16143 ,  C12N2770/24234 ,  Y02A50/41

摘要： The present invention relates to recombinant HCMV (human cytomegalovirus) expressing a pp65 polypeptide or fragment thereof fused to a heterologous or non-native polypeptide, in particular immunogenic and/or antigenic polypeptides. In particular, the heterologous gene products include antigenic or immunogenic polypeptides from a variety of pathogens, cellular genes, tumor antigens, and viruses. The recombinant viruses may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

摘要翻译： 本发明涉及表达与异源或非天然多肽，特别是免疫原性和/或抗原多肽融合的pp65多肽或其片段的重组HCMV（人巨细胞病毒）。 特别地，异源基因产物包括来自多种病原体，细胞基因，肿瘤抗原和病毒的抗原性或免疫原性多肽。 重组病毒可有利地用于疫苗制剂，包括针对各种病原体和抗原的疫苗。

公开(公告)号：US20070276130A1

公开(公告)日：2007-11-29

申请号：US11649191

申请日：2007-01-03

申请人： Philip Dormitzer ,  Stephen Harrison ,  Harry Greenberg ,  Joshua Yoder

发明人： Philip Dormitzer ,  Stephen Harrison ,  Harry Greenberg ,  Joshua Yoder

IPC分类号： C07K14/08

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/14143 ,  C12N2720/12322

摘要： The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.

摘要翻译： 本发明涉及可以包含抗轮状病毒感染的亚基疫苗的新型重组多肽抗原。 此外，本发明涉及在诊断，治疗和预防轮状病毒感染中使用所述抗原的方法。

公开(公告)号：USD249884S

公开(公告)日：1978-10-10

申请号：US694141

申请日：1976-06-09

申请人： Harry Greenberg

设计人： Harry Greenberg

公开(公告)号：US4193077A

公开(公告)日：1980-03-11

申请号：US840833

申请日：1977-10-11

申请人： Harry Greenberg ,  Richard Auerbach

发明人： Harry Greenberg ,  Richard Auerbach

IPC分类号： H01Q1/00 ,  H01Q1/36 ,  H01Q3/24 ,  H01Q3/26 ,  H01Q9/28 ,  H01Q21/29 ,  H01Q21/26

CPC分类号： H01Q21/29 ,  H01Q3/26

摘要： An electrically directable antenna system is provided which is tunable to individual stations in the FM band. The antenna system includes a pair of crossed, forshortened dipole components which are arranged to be mutually perpendicular. Each of the dipole components includes a pair of longitudinally aligned arms which are flared at their outer ends so as to be shaped generally like an arrow. At their inner ends, these arms are connected to a narrow bandwidth tuner network which is designed to resonate the dipole components at a frequency corresponding to a selected station and to impedance match each of the dipole components to the input of the FM receiver. The tuner network includes a bandwidth control, which is operable to produce a predetermined impedance mismatch between the dipole components and the receiver input so that, without changing the frequency to which the antenna system is tuned, the overall antenna system gain can be made substantially constant over the entire FM band. The signals from the four dipole arms, as coupled through the tuner network, are selectively combined in a direction selector switch so that the signal provided from the switch to the receiver input is either: one of the dipole component signals, the sum of the two dipole component signals, or the difference between the two dipole component signals. The particular signal applied to the receiver determines the directionality of the antenna system.

摘要翻译： 提供了可调谐到FM频带中的各个站的电可定向天线系统。 天线系统包括一对交叉的，被套用的偶极子组件，其被布置成相互垂直。 每个偶极子部件包括一对纵向对准的臂，其在其外端处被扩张，以便大致如箭头所示的形状。 在它们的内端，这些臂连接到窄带调谐器网络，该窄带调谐器网络被设计成以对应于所选择的站的频率谐振偶极子分量，并且将每个偶极子分量阻抗匹配到FM接收机的输入。 调谐器网络包括带宽控制，其可操作以在偶极子分量和接收器输入之间产生预定的阻抗失配，使得在不改变天线系统调谐的频率的情况下，可以使总体天线系统增益基本恒定 在整个FM频段。 通过调谐器网络耦合的来自四个偶极臂的信号被选择性地组合在方向选择器开关上，使得从开关到接收器输入端提供的信号是：偶极分量信号之一，二者之和 偶极分量信号，或两个偶极分量信号之间的差。 施加到接收机的特定信号确定天线系统的方向性。