公开(公告)号：US5064856A

公开(公告)日：1991-11-12

申请号：US387668

申请日：1989-07-31

申请人： George M. Garrity ,  Robert Giacobbe ,  Michael D. Greenspan ,  Otto D. Hensens ,  Henry Joshua ,  Maria T. D. Matas ,  Isabel Martin ,  James A. Milligan ,  Sagrario M. del Val ,  Walter Rozdilsky ,  Janet C. Onishi ,  Jerrold M. Liesch

发明人： George M. Garrity ,  Robert Giacobbe ,  Michael D. Greenspan ,  Otto D. Hensens ,  Henry Joshua ,  Maria T. D. Matas ,  Isabel Martin ,  James A. Milligan ,  Sagrario M. del Val ,  Walter Rozdilsky ,  Janet C. Onishi ,  Jerrold M. Liesch

IPC分类号： C12P17/02 ,  A61K31/34 ,  A61K31/365 ,  A61P3/06 ,  C07D303/40 ,  C07D493/10 ,  C07D493/20 ,  C12N1/14 ,  C12N9/99 ,  C12P17/18 ,  C12R1/00 ,  C12R1/645

CPC分类号： C07D493/10 ,  C07D303/40

摘要： Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

公开(公告)号：US5075307A

公开(公告)日：1991-12-24

申请号：US78615

申请日：1987-07-28

申请人： Maria T. D. Matas ,  Dan A. Ostlind ,  Luis Punsola ,  Sagrario Moohales del Val

发明人： Maria T. D. Matas ,  Dan A. Ostlind ,  Luis Punsola ,  Sagrario Moohales del Val

IPC分类号： A23K20/195 ,  A61K31/495 ,  A61K31/55 ,  A61P33/00 ,  C07D491/22 ,  C12N1/14 ,  C12P17/18 ,  C12R1/80

CPC分类号： C07D491/22 ,  A61K31/55 ,  C12N1/14 ,  Y10S435/933

摘要： Paraherquamide and dihydroparaherquamide, known compounds, are disclosed as having antiparasitic activity. The compounds are fungal metabolites isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of Penicillium charlesii. Compositions including paraherquamide and dihydroparaherquamide as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as processes for the preparation of paraherquamide from the newly isolated fungus.