公开(公告)号：US20050171015A1

公开(公告)日：2005-08-04

申请号：US10978672

申请日：2004-11-01

申请人： Gerald Crabtree ,  Monte Winslow

发明人： Gerald Crabtree ,  Monte Winslow

IPC分类号： A61K38/18

CPC分类号： A61K38/465 ,  A61K38/1709 ,  G01N33/5035 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/108

摘要： The present invention provides methods for (i) reducing loss of bone mass or bone density, (ii) increasing bone mass or bone density, (iii) maintaining bone mass or bone density, and/or (iv) reducing loss of calcium from bone, comprising: administering to a subject a therapeutically effective amount of an NFAT agonist. The method could be used for treating, preventing or delaying a bone condition. The invention further provides a method for promoting healing of bone fractures or bone defects comprising: administering to a subject a therapeutically effective amount of an NFAT agonist. Compositions comprising NFAT agonists can also be used for the in vitro or in vivo generation of bone tissue. The invention also provides screening methods for agents which promotes, maintains, or reduces the loss of, bone mass, and the use of such agents for therapeutic purposes.

摘要翻译： 本发明提供了（i）减少骨质量或骨密度损失的方法，（ii）增加骨质量或骨密度，（iii）维持骨量或骨密度，和/或（iv）减少骨骼中钙的损失 包括：向受试者施用治疗有效量的NFAT激动剂。 该方法可用于治疗，预防或延缓骨骼状况。 本发明进一步提供了促进骨折或骨缺损愈合的方法，其包括：向受试者施用治疗有效量的NFAT激动剂。 包含NFAT激动剂的组合物也可用于骨组织的体外或体内产生。 本发明还提供用于促进，维持或减少骨质量损失的试剂的筛选方法以及用于治疗目的的这些试剂的使用。