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公开(公告)号:US4762711A
公开(公告)日:1988-08-09
申请号:US833102
申请日:1986-02-25
IPC分类号: A61K39/018 , C12N1/10
CPC分类号: A61K39/018
摘要: A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slow-growing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.
摘要翻译: 用于牛狒狒病的活疫苗包括用克隆的巴贝虫群体寄生的可行的牛红细胞,克隆菌株快速生长,无毒,并且当施用时产生温和但免疫的感染。 该疫苗没有缓慢生长的毒素B.牛牛。 疫苗中使用的克隆菌株通过进行性稀释培养从有毒和无毒婴儿的天然混合物制备,以获得含有单个寄生虫的培养物,在有利的生长条件下繁殖单个寄生虫,并选择快速生长的无毒素克隆系 体外或体内繁殖以制备疫苗。
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公开(公告)号:US4590072A
公开(公告)日:1986-05-20
申请号:US663844
申请日:1984-10-31
IPC分类号: A61K39/018 , C12N1/10
CPC分类号: A61K39/018
摘要: A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slow-growing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.
摘要翻译: 用于牛狒狒病的活疫苗包括用克隆的巴贝虫群体寄生的可行的牛红细胞,克隆菌株快速生长,无毒,并且当施用时产生温和但免疫的感染。 该疫苗没有缓慢生长的毒素B.牛牛。 疫苗中使用的克隆菌株通过进行性稀释培养从有毒和无毒婴儿的天然混合物制备,以获得含有单个寄生虫的培养物,在有利的生长条件下繁殖单个寄生虫,并选择快速生长的无毒素克隆系 体外或体内繁殖以制备疫苗。
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