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1.发明申请PROLONGED RELEASE FORMULATION OF ACTIVE PRINCIPLES HAVING A PH-DEPENDENT SOLUBILITY 审中-公开具有PH依赖性溶解性的活性原理的广泛释放配方公开(公告)号：US20080089936A1
公开(公告)日：2008-04-17
申请号：US11949291
申请日：2007-12-03
申请人： Gerard ALAUX , Frederic ANDRE , Gareth LEWIS , Veronique SERRE
发明人： Gerard ALAUX , Frederic ANDRE , Gareth LEWIS , Veronique SERRE
IPC分类号： A61K9/22 , A61K31/506 , A61K31/454
CPC分类号： A61K9/209 , A61K9/2013 , A61K9/2054 , A61K31/437
摘要： The invention concerns a novel formulation for prolonged release of an active principle having a pH-dependent solubility. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises one or more acidifying agents in the form of an acid salt of an organic acid.
摘要翻译： 本发明涉及用于延长释放具有pH依赖性溶解度的活性成分的新型制剂。 本发明的制剂包含基于含有特定剂量的活性成分的亲水性聚合物的基质载体，并且还包含一种或多种有机酸的酸盐形式的酸化剂。
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2.发明申请PHARMACEUTICAL DOSAGE FORMS FOR CONTROLLED RELEASE PRODUCING AT LEAST A TIMED PULSE 审中-公开用于控制释放的药物剂型至少产生一个定时脉冲公开(公告)号：US20080175910A1
公开(公告)日：2008-07-24
申请号：US12053833
申请日：2008-03-24
CPC分类号： A61K9/5078 , A61K9/5015 , A61K9/5026
摘要： The present invention relates to delayed release coated cores comprising an active substance in their core and a polymer coating comprising at least one or more ammonio methacrylate copolymer, characterized in that the core comprises at least a surfactant; to monolithic or multiparticulate pharmaceutical dosage forms comprising such delayed release coated cores and to their method of manufacture.
摘要翻译： 本发明涉及包含其核心中的活性物质和包含至少一种或多种甲基丙烯酸铵共聚物的聚合物涂层的延迟释放涂覆的芯，其特征在于，芯包含至少一种表面活性剂; 包括这种延迟释放的包覆芯的整体或多颗粒药物剂型及其制备方法。
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