公开(公告)号：US08236827B2

公开(公告)日：2012-08-07

申请号：US12478587

申请日：2009-06-04

申请人： Gerard Andrew Potter ,  Philip Huxley ,  Kenneth James Beresford

发明人： Gerard Andrew Potter ,  Philip Huxley ,  Kenneth James Beresford

IPC分类号： A01N43/40 ,  A61K31/44 ,  C07D405/00

CPC分类号： C07D213/64 ,  C07D405/04

摘要： A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: wherein: R1, R2 and R3 are independently H or lower alkyl; R4, R5, R6, R7 and R8 are independently H, halo, lower alkyl or —O-lower alkyl, provided that at least one is —O-lower alkyl; or at least one pair of R4 to R8, the members of which pair are adjacent to one another on the ring, are conjoined to form —O—(CR14R15)n—O—, where n is 1 or 2 and R14 and R15 are independently H or lower alkyl, and the remainder of R4 to R8 are independently H, halo, lower alkyl or —O-lower alkyl; and R9, R10, R11, R12 and R13 are independently H, halo, lower alkyl or —O— lower alkyl, provided that at least one is —O-lower alkyl; or at least one pair of R9 to R13, the members of which pair are adjacent to one another on the ring, are conjoined to form —O—(CR16R17)m—O—, where m is 1 or 2 and R16 and R17 are independently H or lower alkyl, and the remainder of R9 to R13 are independently H, halo, lower alkyl or —O-lower alkyl.

摘要翻译： 一种用于治疗增殖性疾病如癌症的化合物，具有下式：其中：R1，R2和R3独立地为H或低级烷基; R 4，R 5，R 6，R 7和R 8独立地为H，卤素，低级烷基或-O-低级烷基，条件是至少一个为-O-低级烷基; 或至少一对R4至R8（其成对在环上彼此相邻）被结合形成-O-（CR14R15）n-O-，其中n为1或2，R14和R15为 独立地是H或低级烷基，R4至R8的其余部分独立地为H，卤素，低级烷基或-O-低级烷基; 并且R 9，R 10，R 11，R 12和R 13独立地为H，卤素，低级烷基或-O-低级烷基，条件是至少一个为-O-低级烷基; 或至少有一对R 9至R 13（其成对在环上彼此相邻）结合形成-O-（CR 16 R 17）m -O-，其中m为1或2，R 16和R 17为 独立地是H或低级烷基，R 9至R 13的其余部分独立地为H，卤素，低级烷基或-O-低级烷基。