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![Substituted 8,8a-dihydro-3ah-indeno[1,2-d]thiazoles, processes for their preparation and their use as medicaments](/abs-image/US/2002/06/25/US06410577B1/abs.jpg.150x150.jpg)
公开(公告)号：US06410577B1
公开(公告)日：2002-06-25
申请号：US09790905
申请日：2001-02-23
IPC分类号： C07D27760
摘要： The invention relates to substituted 8,8a-dihydro-3aH-indeno[1,2-d]thiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
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2.发明授权公开(公告)号：US06387935B1
公开(公告)日：2002-05-14
申请号：US09706351
申请日：2000-11-06
IPC分类号： A61K31428
CPC分类号： C07D277/60 , A61K31/425 , A61K31/428
摘要： The invention relates to polycyclic dihydrothiazoles, and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are according to formula I: in which the radicals have the meanings indicated, and their physiologically acceptable salts and process for their preparation are described. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 本发明涉及多环二氢噻唑及其生理上可接受的盐和生理功能衍生物。 该化合物是根据式I所示：其中基团具有所示的含义，并描述了它们的生理上可接受的盐及其制备方法。 这些化合物适用于例如用作止痛剂。
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![8,8A-DIHYDROINDENO[1,2-D]THIAZOLE DERIVATIVES WHICH CARRY IN THE 2-POSITION A SUBSTITUENT HAVING A SULFONAMIDE STRUCTURE OR SULFONE STRUCTURE; PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS](/abs-image/US/2002/09/03/US06444669B1/abs.jpg.150x150.jpg)
公开(公告)号：US06444669B1
公开(公告)日：2002-09-03
申请号：US10046989
申请日：2002-01-17
IPC分类号： A61K31535
CPC分类号： C07D277/60
摘要： 8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
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![8,8A-DIHYDROINDENO[1,2-D]THIAZOLE DERIVATIVES WHICH CARRY IN THE 2-POSITION A SUBSTITUENT HAVING A SULFONAMIDE STRUCTURE OR SULFONE STRUCTURE; PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS](/abs-image/US/2002/03/05/US06352987B2/abs.jpg.150x150.jpg)
4.发明授权8,8A-DIHYDROINDENO[1,2-D]THIAZOLE DERIVATIVES WHICH CARRY IN THE 2-POSITION A SUBSTITUENT HAVING A SULFONAMIDE STRUCTURE OR SULFONE STRUCTURE; PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权8,8-二氢二茚并[1,2-D]噻唑衍生物，其在2-位具有磺酰胺结构或磺酰结构的取代基; 其制备方法及其作为药物使用公开(公告)号：US06352987B2
公开(公告)日：2002-03-05
申请号：US09792049
申请日：2001-02-26
IPC分类号： A61K31428
CPC分类号： C07D277/60
摘要： 8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
摘要翻译： 具有2位具有磺酰胺结构或砜结构的取代基的8,8a-二氢茚并[1,2-d]噻唑衍生物; 其制备方法及其作为药物的用途本发明涉及多环二氢噻唑及其生理上可接受的盐和生理功能衍生物。其中基团如上所定义的式I化合物及其生理学上可接受的盐及其制备方法是 描述。 所述化合物例如适合作为抗精神病药。
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5.发明授权Polycyclic 2-aminodihydrothiazole systems, processes for their preparation and their use as pharmaceuticals 有权多环2-氨基二氢噻唑系统，其制备方法及其作为药物的用途公开(公告)号：US06235763B1
公开(公告)日：2001-05-22
申请号：US09499350
申请日：2000-02-08
申请人： Gerhard Jaehne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jaehne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K31381
CPC分类号： C07D277/60
摘要： The invention relates to polycyclc 2-aminodihydrothiazole systems and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
摘要翻译： 本发明涉及多环C 2-氨基二氢噻唑体系及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 所述化合物例如适合作为抗精神病药。
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6.发明授权Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use 有权C2取代的茚满-1-醇化合物的衍生物，其制备和使用方法公开(公告)号：US06717008B2
公开(公告)日：2004-04-06
申请号：US10231365
申请日：2002-08-30
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07C30900
CPC分类号： C07C317/20 , C07C323/17 , C07C2602/08
摘要： Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 公开了C2-取代的茚满-1-醇化合物的衍生物，其制备方法及其应用。 特别地，本发明涉及式I化合物及其生理上可接受的盐和生理功能衍生物。 这些化合物适用于例如用作止痛剂。
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7.发明授权Use of C2-substituted indan-1-ol systems for preparing medicaments for the prophylaxis or treatment of obesity 有权使用C2取代的茚满-1-醇系统制备用于预防或治疗肥胖症的药物公开(公告)号：US07763662B2
公开(公告)日：2010-07-27
申请号：US11006164
申请日：2004-12-07
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61K31/10
CPC分类号： A61K31/255
摘要： Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of C2-substituted indan-1-ol systems and their physiologically acceptable salts and physiologically functional derivatives. Compounds for use in the methods of the embodiments of the invention include compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts.
摘要翻译： 本发明的实施方案涉及减轻哺乳动物体重和用于预防或治疗肥胖症的方法，其包括施用C 2-取代的茚满-1-醇体系及其生理学上可接受的盐和生理功能衍生物。 用于本发明实施方案的方法的化合物包括其中基团如所定义的式（I）化合物及其生理学上可接受的盐。
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8.发明授权Derivatives of C2-substituted indan-1-ol systems for the prophylaxis or treatment of obesity 有权用于预防或治疗肥胖症的C2取代的茚满-1-醇系统的衍生物公开(公告)号：US06667345B2
公开(公告)日：2003-12-23
申请号：US10230379
申请日：2002-08-29
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61K3110
CPC分类号： A61K31/365 , A61K31/10 , A61K38/2264
摘要： Derivatives of C2-substituted indan-1-ol compounds of the formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity are disclosed herein. Compositions comprising the same, methods for preparing the instant compounds, and methods for reducing weight in mammals and for the prophylaxis or treatment of obesity are also described.
摘要翻译： 式I的C2-取代茚满-1-醇化合物的衍生物：其生理上可接受的盐及其用于预防或治疗肥胖症的生理功能衍生物。 还描述了包含其的组合物，制备本发明化合物的方法，以及用于减轻哺乳动物体重和预防或治疗肥胖症的方法。
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9.发明授权Use of C2-substituted indan-1-one systems for preparing medicaments for the treatment of obesity 失效使用C2取代的茚满-1-酮系统制备用于治疗肥胖症的药物公开(公告)号：US06946492B2
公开(公告)日：2005-09-20
申请号：US10231162
申请日：2002-08-30
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61K31/381 , A61K31/10 , A61K31/16 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/198 , A61K31/225 , A61K31/365 , A61K31/404 , A61K31/424 , A61K31/4402 , A61K31/505 , A61K38/22 , A61P3/04 , A61P3/10 , A61P9/10 , A61P9/12 , C07D233/54 , A61K31/12 , A61K31/095 , A61K31/13 , A61K31/38 , A61K31/41
CPC分类号： A61K38/2264 , A61K31/10 , A61K31/365
摘要： Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of C2-substituted indan-1-one systems and their physiologically acceptable salts and physiologically functional derivatives. Compounds for use in methods of embodiments of the invention may include compounds of the formula in which the radicals are as defined, and their physiologically acceptable salts.
摘要翻译： 本发明的实施方案涉及降低哺乳动物体重和用于预防或治疗肥胖症的方法，包括施用C2-取代的茚满-1-酮系统及其生理上可接受的盐和生理功能衍生物。 用于本发明实施方案方法的化合物可包括其中基团如所定义的下式化合物及其生理上可接受的盐。
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10.发明申请Use of C2-substituted indan-1-ol systems for preparing medicaments for the prophylaxis or treatment of obesity 有权使用C2取代的茚满-1-醇系统制备用于预防或治疗肥胖症的药物公开(公告)号：US20050080057A1
公开(公告)日：2005-04-14
申请号：US11006164
申请日：2004-12-07
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61P3/04 , A61K31/10 , A61K31/255 , A61P3/00 , A61P5/48 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/54 , A61K31/655 , A61K31/135 , A61K31/277 , A61K31/325 , A61K31/41
CPC分类号： A61K31/255
摘要： Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of of C2-substituted indan-1-ol systems and their physiologically acceptable salts and physiologically functional derivatives. Compounds for use in the methods of the embodiments of the invention include compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts.
摘要翻译： 本发明的实施方案涉及降低哺乳动物体重和用于预防或治疗肥胖症的方法，其包括施用C2-取代的茚满-1-醇体系及其生理学上可接受的盐和生理功能衍生物。 用于本发明实施方案的方法的化合物包括其中基团如所定义的式（I）化合物及其生理学上可接受的盐。
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