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1.发明申请公开(公告)号：US20190320974A1
公开(公告)日：2019-10-24
申请号：US16389513
申请日：2019-04-19
申请人： Ghadh Alzamzmi , Chih-Yun Pai , Dmitry Goldgof , Rangachar Kasturi , Terri Ashmeade , Yu Sun
发明人： Ghadh Alzamzmi , Chih-Yun Pai , Dmitry Goldgof , Rangachar Kasturi , Terri Ashmeade , Yu Sun
IPC分类号： A61B5/00
摘要： A system and method of automatically assessing pediatric and neonatal pain using facial expressions along with crying sounds, body movement, and vital signs change to improve the diagnosis and treatment of pain in the pediatric patient population.
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公开(公告)号：US20150359240A1
公开(公告)日：2015-12-17
申请号：US14739769
申请日：2015-06-15
CPC分类号： A23C9/206 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/324 , A23V2250/542 , A23V2250/54248
摘要： Donor milk has become a standard of care for feeding preterm infants, particularly those with gestational ages of 34 weeks or less, whose mothers are not lactating or not producing sufficient milk quantities. However, prior to distribution, donor milk is required to undergo pasteurization, typically using the Holder method, which is believed to destroy immune proteins in the milk and denature many other proteins. Donor milk has been found to contain concentrations of chemokines, cytokines, and growth factors, evidencing the value of donor milk over formula. In light of the findings, donor milk is supplemented with chemokines, cytokines, and growth factors that are found to be lower in the donor milk as compared to mother's own milk.
摘要翻译： 供体牛奶已经成为喂养早产儿，特别是孕龄不超过34周的早产儿，其母亲没有哺乳或没有产生足够的奶量的标准。 然而，在分配之前，供体牛奶需要进行巴氏灭菌，通常使用Holder方法，据信可以破坏牛奶中的免疫蛋白质并使许多其他蛋白质变性。 已经发现供体牛奶含有趋化因子，细胞因子和生长因子的浓度，证明供体奶超过配方的价值。 鉴于研究结果，与母亲自己的牛奶相比，供体乳补充了供体乳中趋化因子，细胞因子和生长因子，这些因子与供体乳相比较低。
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3.发明授权Method of supplementing cytokine, chemokine and growth factors in donor human milk 有权补充供体人乳中细胞因子，趋化因子和生长因子的方法公开(公告)号：US09345249B2
公开(公告)日：2016-05-24
申请号：US14739769
申请日：2015-06-15
CPC分类号： A23C9/206 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/324 , A23V2250/542 , A23V2250/54248
摘要： Donor milk has become a standard of care for feeding preterm infants, particularly those with gestational ages of 34 weeks or less, whose mothers are not lactating or not producing sufficient milk quantities. However, prior to distribution, donor milk is required to undergo pasteurization, typically using the Holder method, which is believed to destroy immune proteins in the milk and denature many other proteins. Donor milk has been found to contain concentrations of chemokines, cytokines, and growth factors, evidencing the value of donor milk over formula. In light of the findings, donor milk is supplemented with chemokines, cytokines, and growth factors that are found to be lower in the donor milk as compared to mother's own milk.
摘要翻译： 供体牛奶已经成为喂养早产儿，特别是孕龄不超过34周的早产儿，其母亲没有哺乳或没有产生足够的奶量的标准。 然而，在分配之前，供体牛奶需要进行巴氏灭菌，通常使用Holder方法，据信可以破坏牛奶中的免疫蛋白质并使许多其他蛋白质变性。 已经发现供体牛奶含有趋化因子，细胞因子和生长因子的浓度，证明供体奶超过配方的价值。 鉴于研究结果，与母亲自己的牛奶相比，供体乳补充了供体乳中趋化因子，细胞因子和生长因子，这些因子与供体乳相比较低。
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