公开(公告)号：US20090054433A1

公开(公告)日：2009-02-26

申请号：US12195951

申请日：2008-08-21

申请人： Ghil Soo NAM ,  Hye Whon RHIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Kyungl Il CHOI ,  Seung Yeol NAH

发明人： Ghil Soo NAM ,  Hye Whon RHIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Kyungl Il CHOI ,  Seung Yeol NAH

IPC分类号： A61K31/5377 ,  A61K31/517 ,  A61P25/00

CPC分类号： A61K31/517 ,  A61K31/5377

摘要： The present invention relates to a pharmaceutical composition containing one or more quinazoline compounds as an active ingredient, which has antagonistic activity against serotonin 5-HT3A and is effective for the prevention and treatment of central nervous system (CNS) diseases, including emesis, nausea, alcoholism, drug abuse, depression, compulsive neurosis, anxiety, seizure, Alzheimer's disease, Parkinson's disease, Huntington's chorea, psychosis, schizophrenia, suicidal tendency, sleep disorder, appetite disorder and migraine.

摘要翻译： 本发明涉及一种含有一种或多种喹唑啉化合物作为活性成分的药物组合物，其对5-羟色胺5-HT3A具有拮抗作用，对预防和治疗中枢神经系统（CNS）疾病有效，包括呕吐，恶心， 酒精中毒，药物滥用，抑郁症，强迫性神经症，焦虑症，癫痫发作，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，精神病，精神分裂症，自杀倾向，睡眠障碍，食欲障碍和偏头痛。