公开(公告)号：US20240207315A1

公开(公告)日：2024-06-27

申请号：US18397019

申请日：2023-12-27

申请人： Gilboa Therapeutics LTD

发明人： Noam PILPEL ,  Peleg RIDER ,  Yaron CARMI ,  Shahar DOTAN ,  Diana RASOULOUNIRIANA ,  Hana SHPILT

IPC分类号： A61K35/17 ,  A61K39/00 ,  C07K14/735

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  C07K14/70535 ,  A61K2239/15 ,  A61K2239/21 ,  A61K2239/22

摘要： Chimeric receptors are provided. Accordingly, there is provided a chimeric receptor comprising an extracellular binding domain and a heterologous amino acid sequence capable of recruiting a co-receptor comprising an intracellular signaling domain, such that upon binding of the extracellular binding domain to its target the signaling is transmitted in a cell expressing the chimeric receptor and the co-receptor. Also provided are protein complexes comprising the receptors, cells expressing same and uses thereof.