公开(公告)号：US20060035839A1

公开(公告)日：2006-02-16

申请号：US10516083

申请日：2003-05-28

申请人： Gilles Francois Guichard ,  Sylvie Victorine Lucienne Fournel ,  Alberto Bianco ,  Johan Heobeke ,  Sylviane Muller

发明人： Gilles Francois Guichard ,  Sylvie Victorine Lucienne Fournel ,  Alberto Bianco ,  Johan Heobeke ,  Sylviane Muller

IPC分类号： A61K38/10

CPC分类号： C07K5/0815 ,  A61K38/00 ,  C07K5/1019 ,  C07K14/525 ,  C07K14/70575 ,  Y02A50/414

摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

摘要翻译： 本发明涉及可以模拟天然多聚体蛋白质配体的多聚体分子。 本发明还涉及如上定义的多聚体分子，其特征在于其具有以下通式：A-X n n其中：n等于3,4,5或6; A表示通过至少三个胺官能团或COOH官能团官能化的化学基团; 并且X表示D，BD或B（D）-D'基团，其中B是间隔基，D和D'是对应于衍生自配体并选自形成界面的残余物质的序列的肽或假肽 与受体并可与受体相互作用。