公开(公告)号：US20050159585A1

公开(公告)日：2005-07-21

申请号：US11076861

申请日：2005-03-11

申请人： Gilles Guichard ,  Marc Rodriguez ,  Viencent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

发明人： Gilles Guichard ,  Marc Rodriguez ,  Viencent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

IPC分类号： C07D401/12 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4725 ,  A61P31/18 ,  A61P37/02 ,  A61P43/00 ,  C07C263/12 ,  C07C265/04 ,  C07C265/12 ,  C07C273/18 ,  C07C275/14 ,  C07C275/16 ,  C07C275/28 ,  C07D207/40 ,  C07D207/404 ,  C07D259/00 ,  C07D403/12 ,  C08G71/02 ,  C07K5/12

CPC分类号： C07D207/404 ,  C07C275/14 ,  C08G71/02

摘要： Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.

公开(公告)号：US20050159584A1

公开(公告)日：2005-07-21

申请号：US11077257

申请日：2005-03-11

申请人： Gilles Guichard ,  Marc Rodriguez ,  Vincent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

发明人： Gilles Guichard ,  Marc Rodriguez ,  Vincent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

IPC分类号： C07D401/12 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4725 ,  A61P31/18 ,  A61P37/02 ,  A61P43/00 ,  C07C263/12 ,  C07C265/04 ,  C07C265/12 ,  C07C273/18 ,  C07C275/14 ,  C07C275/16 ,  C07C275/28 ,  C07D207/40 ,  C07D207/404 ,  C07D259/00 ,  C07D403/12 ,  C08G71/02 ,  C07K14/47 ,  C07K7/06

CPC分类号： C07D207/404 ,  C07C275/14 ,  C08G71/02

摘要： Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.

摘要翻译： 由保护氨基的氨基酸衍生物制备稳定的氨基甲酸活化衍生物的方法，其包括至少一种被保护的氨基和活性的氨基甲酸功能。 该方法包括：a）将氨基酸衍生物的-COOH基团转化为-CON 3 N 3基团以获得酰基叠氮化物的步骤; b）将酰基叠氮化物的-CON 3 N 3基团转化为-NCO基团以获得异氰酸酯的步骤; c）处理异氰酸酯以获得稳定的氨基甲酸衍生物的步骤。