公开(公告)号：US06706286B1

公开(公告)日：2004-03-16

申请号：US09744869

申请日：2001-01-29

申请人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

发明人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

IPC分类号： A61K914

CPC分类号： A61K9/145 ,  A61K9/0056 ,  A61K9/209

摘要： Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titre of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.

摘要翻译： 处于干燥状态的蔗糖凝胶以粒径分布为100至1000μm的多孔颗粒形式，粉末床的表观密度为0.7至0.9g / ml，沉降指数为5至15％，和 残余湿度在5至15％之间，以及相应的制备方法，其包括用粉状硫糖铝凝胶的稀释溶液的微波处理，硫糖铝滴定剂为20至70重量％。 ％。 该固体产品可有利地用于制备含有它作为单一活性成分的固体药物组合物，或者作为活性成分含有可能引起胃粘膜损害的物质的固体组合物的包衣。

公开(公告)号：US06773722B2

公开(公告)日：2004-08-10

申请号：US10449266

申请日：2003-05-29

申请人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

发明人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

IPC分类号： A61K928

CPC分类号： A61K9/145 ,  A61K9/0056 ,  A61K9/209

摘要： Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titer of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.

摘要翻译： 处于干燥状态的蔗糖凝胶以粒径分布为100至1000μm的多孔颗粒形式，粉末床的表观密度为0.7至0.9g / ml，沉降指数为5至15％，和 残余湿度在5至15％之间，以及相应的制备方法，其包括用微粉硫酸铝凝胶的稀释溶液的微波处理，硫糖铝滴定度为20至70重量％。 ％。 该固体产品可有利地用于制备含有它作为单一活性成分的固体药物组合物，或者作为活性成分含有可能引起胃粘膜损害的物质的固体组合物的包衣。