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1.发明申请Novel clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said protein 有权具有改变的纤溶酶原激活特征的新型凝块特异性链激酶蛋白和用于制备所述蛋白质的方法公开(公告)号：US20050260598A1
公开(公告)日：2005-11-24
申请号：US10631558
申请日：2003-07-31
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
IPC分类号： A61K38/00 , C07H21/04 , C07K14/315 , C07K14/78 , C07K19/00 , C12N1/21 , C12N9/12 , C12N9/70 , C12N15/58 , C12Q1/68
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译： 具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。
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2.发明授权Nucleic acid molecules encoding clot-specific streptokinase fusion proteins possessing altered plasminogen activation characteristics 有权编码凝块特异性链激酶融合蛋白的核酸分子具有改变的纤溶酶原激活特征公开(公告)号：US07250503B2
公开(公告)日：2007-07-31
申请号：US10631558
申请日：2003-07-31
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译： 本发明提供编码具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质的多核苷酸，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。
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3.发明授权Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for their preparation 有权具有改变的纤溶酶原激活特征的凝块特异性链激酶蛋白及其制备方法公开(公告)号：US07163817B2
公开(公告)日：2007-01-16
申请号：US09940235
申请日：2001-08-27
申请人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahni , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： The invention disclosed herein provides clot specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译： 本文公开的本发明提供具有改变的纤溶酶原特征的凝血特异性链激酶蛋白，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。
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4.发明申请Novel clot-specific steptokinase proteins possessing altered plasminogen activation-characteristics and a process for the preparation of said proteins 审中-公开具有改变的纤溶酶原激活特征的新型凝块特异性步进激酶蛋白和用于制备所述蛋白质的方法公开(公告)号：US20070287660A1
公开(公告)日：2007-12-13
申请号：US11605480
申请日：2006-11-29
申请人： Girish Sahai , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
发明人： Girish Sahai , Rajesh Kumar , Chaiti Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
CPC分类号： C07K14/78 , A61K38/00 , C07K14/3153 , C07K19/00 , C07K2319/70
摘要： Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
摘要翻译： 具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。
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公开(公告)号：US08779110B2
公开(公告)日：2014-07-15
申请号：US12997292
申请日：2009-06-23
申请人： Chaiti Roy , Darshan Koticha , Vivek Arthanari
发明人： Chaiti Roy , Darshan Koticha , Vivek Arthanari
CPC分类号： C07K14/505
摘要： The invention provides an efficient method of purification of a modified cytokine. The process includes the use of a chromatographic technique for the purification of the desired cytokine. The purified cytokine can be used as a therapeutic composition.
摘要翻译： 本发明提供了一种有效的纯化修饰细胞因子的方法。 该方法包括使用色谱技术纯化所需的细胞因子。 纯化的细胞因子可以用作治疗组合物。
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公开(公告)号：US20110098452A1
公开(公告)日：2011-04-28
申请号：US12997292
申请日：2009-06-23
申请人： Chaiti Roy , Darshan Koticha , A. Vivek
发明人： Chaiti Roy , Darshan Koticha , A. Vivek
IPC分类号： C07K14/505
CPC分类号： C07K14/505
摘要： The invention provides an efficient method of purification of a modified cytokine. The process includes the use of a chromatographic technique for the purification of the desired cytokine. The purified cytokine can be used as a therapeutic composition.
摘要翻译： 本发明提供了一种有效的纯化修饰细胞因子的方法。 该方法包括使用色谱技术纯化所需的细胞因子。 纯化的细胞因子可以用作治疗组合物。
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