公开(公告)号：US20240083896A1

公开(公告)日：2024-03-14

申请号：US18256982

申请日：2021-12-16

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Xiaoyang DONG ,  Mark Andrew ELBAN ,  Jie GUANG ,  Ming-Hsun HO ,  Tram H. HOANG ,  Joseph J. ROMANO ,  David Glenn WASHBURN

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.