公开(公告)号：US11976057B2

公开(公告)日：2024-05-07

申请号：US17492978

申请日：2021-10-04

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Edward Brnardic ,  Michael Bury ,  Rodolfo Cadilla ,  Jon Collins ,  Yu Guo ,  Anthony Handlon ,  Huijie Li ,  Yue Li ,  Daniel Paone ,  Christie Schulte ,  Barry Shearer ,  Maben Ying ,  Guosen Ye ,  Huichang Zhang ,  Millard Hurst Lambert, III

IPC: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.