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    ICOS binding proteins
    1.
    发明授权
    ICOS binding proteins 有权

    公开(公告)号：US11130811B2

    公开(公告)日：2021-09-28

    申请号：US16441474

    申请日：2019-06-14

    Applicant: GlaxoSmithKline Intellectual Property Development Limited

    Inventor： Yao-Bin Liu ,  Patrick Mayes ,  Radha Shah Parmar

    IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  A61K39/00

    Abstract: The present invention relates to an ICOS binding protein or antigen binding portion thereof that is an agonist to human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said ICOS binding protein or antigen binding portion thereof. Further the ICOS binding proteins or antigen binding portions thereof of the present invention are capable of activating a T cell when placed in contact with said T cell; stimulating T cell proliferation when placed in contact with said T cell and/or inducing cytokine production when placed in contact with said T cell. The present invention relates to ICOS binding proteins or antigen binding portions thereof comprising one or more of: SEQ ID NO: 1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:5; and/or SEQ ID NO:6.

    ICOS binding proteins
    3.
    发明授权
    ICOS binding proteins 有权

    公开(公告)号：US10351627B2

    公开(公告)日：2019-07-16

    申请号：US15246662

    申请日：2016-08-25

    Applicant: GlaxoSmithKline Intellectual Property Development Limited

    Inventor： Yao-Bin Liu ,  Patrick Mayes ,  Radha Shah Parmar

    IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  A61K39/00

    Abstract: The present invention relates to an ICOS binding protein or antigen binding portion thereof that is an agonist to human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said ICOS binding protein or antigen binding portion thereof. Further the ICOS binding proteins or antigen binding portions thereof of the present invention are capable of activating a T cell when placed in contact with said T cell; stimulating T cell proliferation when placed in contact with said T cell and/or inducing cytokine production when placed in contact with said T cell. The present invention relates to ICOS binding proteins or antigen binding portions thereof comprising one or more of: SEQ ID NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:5; and/or SEQ ID NO:6.

    ICOS BINDING PROTEINS
    4.
    发明申请
    ICOS BINDING PROTEINS 有权
    ICOS结合蛋白

    公开(公告)号：US20160215059A1

    公开(公告)日：2016-07-28

    申请号：US15006560

    申请日：2016-01-26

    Applicant: GlaxoSmithKline Intellectual Property Development Limited

    Inventor： Yao-Bin Liu ,  Patrick Mayes ,  Radha Shah Parmar

    IPC: C07K16/28 ,  C07K16/30 ,  A61K45/06

    CPC classification number: C07K16/2818 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

    Abstract: The present invention relates to an ICOS binding protein, or antigen binding portion thereof that is an agonist human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said ICOS binding protein or antigen binding portion thereof. Further the ICOS binding proteins or antigen binding portions thereof of the present invention are capable of activating a T cell when placed in contact with said T cell; stimulating T cell proliferation when placed in contact with said T cell and/or inducing cytokine production when placed in contact with said T cell. The present invention relates to ICOS binding proteins or antigen binding portions thereof comprising one or more oft SEQ ID NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:5; and/or SEQ ID NO:6.

    Abstract translation: 本发明涉及ICOS结合蛋白或其抗原结合部分，其是激动剂人ICOS，并且当其与体内的T细胞接触时不诱导补体，ADCC或CDC，以及治疗癌症，感染性疾病和 /或与所述ICOS结合蛋白或其抗原结合部分的败血症。 此外，本发明的ICOS结合蛋白或其抗原结合部分当与所述T细胞接触时能够激活T细胞; 当与所述T细胞接触时刺激T细胞增殖和/或当与所述T细胞接触时诱导细胞因子产生。 本发明涉及包含SEQ ID NO：1中的一个或多个的ICOS结合蛋白或其抗原结合部分; SEQ ID NO：2; SEQ ID NO：3; SEQ ID NO：4; SEQ ID NO：5; 和/或SEQ ID NO：6。

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