公开(公告)号：US09000159B2

公开(公告)日：2015-04-07

申请号：US14079932

申请日：2013-11-14

申请人： Glenmark Pharmaceuticals, S.A.

发明人： Sachin Sundarlal Chaudhari ,  Sukeerthi Kumar ,  Abraham Thomas ,  Nisha Parag Patil ,  Ashok Bhausaheb Kadam ,  Vishal Govindrao Deshmukh ,  Sachin Vasantrao Dhone ,  Rajendra Prakash Chikhale ,  Neelima Khairatkar-Joshi ,  Indranil Mukhopadhyay

IPC分类号： C07D487/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

摘要翻译： 本文描述的发明涉及式（I）的新型稠合嘧啶二酮衍生物，其是TRPA（瞬时受体电位亚族A）调节剂。 特别地，本文所述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚科A，成员1）调节的疾病，病症和/或病症。 本发明还提供了制备本文所述化合物的方法，其合成中使用的中间体，其药物组合物，以及用于治疗或预防由TRPA1调节的疾病，病症和/或障碍的方法。

公开(公告)号：US20140128603A1

公开(公告)日：2014-05-08

申请号：US14079932

申请日：2013-11-14

申请人： Glenmark Pharmaceuticals, S.A.

发明人： Sachin Sundarlal Chaudhari ,  Sukeerthi Kumar ,  Abraham Thomas ,  Nisha Parag Patil ,  Ashok Bhausaheb Kadam ,  Vishal Govindrao Deshmukh ,  Sachin Vasantrao Dhone ,  Rajendra Prakash Chikhale ,  Neelima Khairatkar-Joshi ,  Indranil Mukhopadhyay

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

摘要翻译： 本文描述的发明涉及式（I）的新型稠合嘧啶二酮衍生物，其是TRPA（瞬时受体电位亚族A）调节剂。 特别地，本文所述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚科A，成员1）调节的疾病，病症和/或病症。 本发明还提供了制备本文所述化合物的方法，其合成中使用的中间体，其药物组合物，以及用于治疗或预防由TRPA1调节的疾病，病症和/或障碍的方法。