公开(公告)号：US20040185097A1

公开(公告)日：2004-09-23

申请号：US10762180

申请日：2004-01-21

申请人： Glenmark Pharmaceuticals Ltd.

发明人： Muthaiyyan Esakki Kannan ,  Anandi Krishnan ,  Beena Amol Sapre ,  Chitra Siddharth Shah ,  Atul Vishvanath Patil

IPC分类号： A61K009/22

CPC分类号： A61K9/2031 ,  A61K9/2059

摘要： Disclosed is a controlled release modifying complex for solid oral controlled release pharmaceutical compositions suitable for once-a-day administration. The composition comprises an active pharmaceutical ingredient, a release modifying complex and other required pharmaceutically acceptable excipients. The release modifying complex comprises a primary release modifying agent, a secondary release modifying agent and an auxiliary release modifying agent or varying combinations thereof, wherein said primary, secondary and auxiliary release modifying agents are present in amounts that synergistically effect and extend the release of active pharmaceutical ingredient.

摘要翻译： 公开了一种适用于每天一次给药的固体口服释药药物组合物的控释缓释复合物。 组合物包含活性药物成分，释放改性复合物和其它所需的药学上可接受的赋形剂。 释放改性复合物包含一级释放调节剂，二级释放改性剂和辅助释放调节剂或其不同组合，其中所述初级，次级和辅助释放调节剂以协同作用和延长活性物质释放的量存在 药物成分。