公开(公告)号：US5585479A

公开(公告)日：1996-12-17

申请号：US136741

申请日：1993-10-12

申请人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

发明人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

IPC分类号： A61K38/00 ,  C12N15/113 ,  C07H21/04

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315

摘要： The present invention provides a method for the treatment of septic shock d inflammatory complications of shock. A process for selectively inhibiting the expression of the human ELAM-I mRNA transcript using at least one oligonucleotide which is substantially complementary to at least a portion of the ELAM-I gene is disclosed, as are composition comprising the oligonucleotide.

摘要翻译： 本发明提供了治疗休克性休克和炎性并发症的方法。 公开了使用至少一种与至少一部分ELAM-1基因互补的寡核苷酸来选择性抑制人ELAM-1 mRNA转录物的表达的方法，以及包含该寡核苷酸的组合物。

公开(公告)号：US5596090A

公开(公告)日：1997-01-21

申请号：US137701

申请日：1993-10-12

申请人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

发明人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

IPC分类号： A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  A61K31/70

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315

摘要： Antisense oligonucleotides complementary to human mRNAs or pre-mRNAs codingor VCAM-I are used in a therapeutic treatment of sepsis (sepsis, the sepsis syndrome, septic shock and all other manifestations of the sepsis disease, including but not inclusive of, adult respiratory distress syndrome, multi-organ failure, or cardiovascular dysfunction).

摘要翻译： 与编码VCAM-1的人mRNA或前体mRNA互补的反义寡核苷酸用于治疗败血症（败血症，败血症综合征，败血症休克和脓毒症疾病的所有其他表现，包括但不包括成人呼吸窘迫 综合征，多器官衰竭或心血管功能障碍）。

公开(公告)号：US5580969A

公开(公告)日：1996-12-03

申请号：US136118

申请日：1993-10-12

申请人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

发明人： Glenn D. Hoke ,  Matthews O. Bradley ,  Taffy J. Williams ,  Che-Hung Lee

IPC分类号： A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  C07H21/02

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315

摘要： The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I mRNA transcript using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I mRNA is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I mRNA and compositions comprising the oligonucleotides.

摘要翻译： 本发明提供了治疗休克性休克和炎性并发症的方法。 公开了使用与ICAM-1 mRNA的至少一部分互补的至少一种寡核苷酸选择性抑制人ICAM-1 mRNA转录物的表达的方法，与ICAM- I mRNA和包含寡核苷酸的组合物。

公开(公告)号：US5691461A

公开(公告)日：1997-11-25

申请号：US229145

申请日：1994-04-18

申请人： David J. Ecker ,  Glenn D. Hoke

发明人： David J. Ecker ,  Glenn D. Hoke

IPC分类号： A61K38/00 ,  C07K14/40 ,  C12N15/113 ,  C07H21/04

CPC分类号： C12N15/113 ,  C07K14/40 ,  A61K38/00 ,  C12N2310/315

摘要： Compositions and methods are provided for the treatment and diagnosis of Candida infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with at least a portion of a Candida mRNA. Preferred targets are the mRNAs which encode .beta.-tubulin, aspartate protease, actin and chitin synthetase, as well as the mRNA's which encode the ribosomal L25 protein, translation elongation factors 1 and 2 (TEF1 and TEF2), the b subunit of ATPase, and cytochrome P450 lanosterol 14.alpha.-demethylase (L1A1). The oligonucleotides comprise nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3' untranslated sequences, 5' cap, and intron/exon junction of the mRNAs. Methods of treating animals suffering from Candida infection are disclosed.

摘要翻译： 提供组合物和方法用于治疗和诊断念珠菌感染。 根据优选实施方案，提供了与至少一部分念珠菌mRNA特异性杂交的寡核苷酸。 优选的靶标是编码β-微管蛋白，天冬氨酸蛋白酶，肌动蛋白和几丁质合成酶的mRNA，以及编码核糖体L25蛋白的mRNA，翻译延伸因子1和2（TEF1和TEF2），ATP酶的b亚基和 细胞色素P450羊毛甾醇14α-甲基化酶（L1A1）。 寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选的实施方案中，寡核苷酸与mRNA的转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列，5'帽和内含子/外显子连接物特异性杂交。 公开了治疗念珠菌感染动物的方法。

公开(公告)号：US20080207545A1

公开(公告)日：2008-08-28

申请号：US11885384

申请日：2004-10-20

申请人： Glenn D. Hoke ,  Thomas P. Nigra

发明人： Glenn D. Hoke ,  Thomas P. Nigra

IPC分类号： A61K31/7088 ,  A61P17/00 ,  A61P35/04 ,  A61P13/00

CPC分类号： A61Q5/006 ,  A61K8/606 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/127 ,  A61K47/10 ,  A61K47/26 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q7/02 ,  A61Q19/00 ,  A61Q19/008 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2320/32

摘要： The invention relates generally to the use of anti-sense oligonucleotides, small interfering RNA, and ribozymes to modulate expression of the human steroid 5α-reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders

摘要翻译： 本发明一般涉及使用反义寡核苷酸，小干扰RNA和核酶来调节人类类固醇5α-还原酶基因的表达，从而调节二氢睾酮（DHT）的水平。 DHT水平升高与各种疾病有关，包括但不限于皮肤病，脱发，多发性和良性前列腺增生。 本发明具体涉及用于治疗和预防障碍的这些反义寡核苷酸，小干扰RNA和核酶的制剂