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公开(公告)号:US08298570B2
公开(公告)日:2012-10-30
申请号:US12031659
申请日:2008-02-14
申请人: Glenn T Huang , Thierry Nivaggioli
发明人: Glenn T Huang , Thierry Nivaggioli
IPC分类号: A61F2/14
CPC分类号: A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要: Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
摘要翻译: 生物相容性眼内植入物包括彼此相关的类固醇和聚合物,以促进类固醇进入眼睛大于约两个月的时间。 类固醇可以与可生物降解的聚合物基质相关联,例如两种可生物降解聚合物的基质。 或者,类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 植入物可以放置在眼睛中以治疗一种或多种眼睛状况。 类固醇从植入物中释放超过约两个月,可能会释放超过几年。
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公开(公告)号:US08263110B2
公开(公告)日:2012-09-11
申请号:US12031656
申请日:2008-02-14
申请人: Glenn T Huang , Thierry Nivaggioli
发明人: Glenn T Huang , Thierry Nivaggioli
IPC分类号: A61F2/02
CPC分类号: A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要: Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
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公开(公告)号:US08506986B2
公开(公告)日:2013-08-13
申请号:US12024014
申请日:2008-01-31
申请人: Glenn T Huang , Brittany Jackson , James A. Burke , Ton Lin , Patrick M. Hughes , Larry A. Wheeler , Rosy Sheng Donn
发明人: Glenn T Huang , Brittany Jackson , James A. Burke , Ton Lin , Patrick M. Hughes , Larry A. Wheeler , Rosy Sheng Donn
IPC分类号: A61K31/498 , A61K9/14
CPC分类号: A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.
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公开(公告)号:US08580292B2
公开(公告)日:2013-11-12
申请号:US12024017
申请日:2008-01-31
申请人: Glenn T Huang , Brittany Jackson , James A. Burke , Ton Lin , Patrick M. Hughes , Larry A. Wheeler , Rosy Sheng Donn
发明人: Glenn T Huang , Brittany Jackson , James A. Burke , Ton Lin , Patrick M. Hughes , Larry A. Wheeler , Rosy Sheng Donn
IPC分类号: A61F2/00 , A61K31/498
CPC分类号: A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.
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