公开(公告)号：US20230235076A1

公开(公告)日：2023-07-27

申请号：US18010858

申请日：2021-06-29

申请人： Glycotope GmbH

发明人： Antje DANIELCZYK ,  Johanna GELLERT ,  Anke FLECHNER ,  Patrik KEHLER

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00

CPC分类号： C07K16/2896 ,  A61K47/6849 ,  A61K47/6817 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/92 ,  C07K2317/73

摘要： The present invention pertains to humanized anti-Lewis Y antibodies which specifically bind to Lewis Y and do not show any cross-reactivity. Especially, the humanized anti-Lewis Y antibodies do not bind to Lewis b or any other blood group carbohydrate antigen. In particular, the present invention is directed to humanized anti-Lewis Y antibodies which are useful in the treatment of cancer.

公开(公告)号：US20210107961A1

公开(公告)日：2021-04-15

申请号：US16971756

申请日：2019-03-01

申请人： Glycotope GmbH

发明人： Johanna GELLERT ,  Patrik KEHLER ,  Anika JÄKEL ,  Laura DIX ,  Antje DANIELCZYK ,  Steffen GOLETZ

IPC分类号： C07K14/54 ,  C07K16/30 ,  A61P35/00

摘要： The present invention pertains to fusion protein constructs comprising an antibody against the cancer antigen MUC1 and IL-15. In particular, the fusion protein constructs activate NK cells and T cells at the cancer site.