公开(公告)号：US06342634B2

公开(公告)日：2002-01-29

申请号：US09880126

申请日：2001-06-14

申请人： Graeme P. Nicholson ,  Mark J. Kan ,  Gareth Williams ,  Michael G. Drew ,  Paul D. Beer

发明人： Graeme P. Nicholson ,  Mark J. Kan ,  Gareth Williams ,  Michael G. Drew ,  Paul D. Beer

IPC分类号： C07C23300

CPC分类号： C07C235/20 ,  C07C235/24 ,  C07C327/42 ,  C07C2603/92 ,  C07D273/00 ,  C22B3/002 ,  G01N27/3335 ,  Y02P10/234

摘要： Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4, are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers

摘要翻译： 公开了式（I）的“酸酰胺”杯芳烃，其中：L是[-CH 2 - ]或[-O-CH 2 -O-]，并且在每个芳基R5之间可以相同或不同，是H，卤素或 C 1 -C 10脂族烃基，C 6 -C 20芳基，其中任何一个可任选被一个或多个卤代或氧代基团取代或被一个或多个氧代基团间隔，并且R 5可以在每个芳基上相同或不同; R1包含任选保护的羧基; R2，R3和R4中的两个基团是H; R2，R3和R4不为H的一个基团包含酰胺基。 酰胺基团可以与第二杯咖啡连接以形成二聚体。 还公开了使用这种杯芳烃用于金属螯合的方法，特别是镧系元素和锕系元素的方法。 还公开了本发明的杯芳烃的杯芳烃二聚体衍生物。 还公开了制备杯芳烃和二聚体的方法

公开(公告)号：US06297395B1

公开(公告)日：2001-10-02

申请号：US09460237

申请日：1999-12-13

申请人： Graeme P. Nicholson ,  Mark J. Kan ,  Gareth Williams ,  Michael G. Drew ,  Paul D. Beer

发明人： Graeme P. Nicholson ,  Mark J. Kan ,  Gareth Williams ,  Michael G. Drew ,  Paul D. Beer

IPC分类号： C07C22900

CPC分类号： C07C235/20 ,  C07C235/24 ,  C07C327/42 ,  C07C2603/92 ,  C07D273/00 ,  C22B3/002 ,  G01N27/3335 ,  Y02P10/234

摘要： Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group; R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, C6-C10 hydrocarbyaryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4 are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers.

摘要翻译： 公开了式（I）的“酸酰胺”杯芳烃，其中：L是[-CH 2 - ]或[-O-CH 2 -O-]，并且在每个芳基之间可以相同或不同; R5是H，卤素或C1-C10脂族烃基，C6-C20芳基，C6-C10烃氧基，其中任何一个可以任选地被一个或多个卤代或氧代基取代或被一个或多个氧代基中断， 并且R 5可以在每个芳基上相同或不同; R1包含任选保护的羧基; R2，R3和R4中的两个基团是H; R2，R3和R4不为H的一个基团包含酰胺基。 酰胺基团可以与第二杯咖啡连接以形成二聚体。 还公开了使用这种杯芳烃用于金属螯合的方法，特别是镧系元素和锕系元素的方法。 还公开了本发明的杯芳烃的杯芳烃二聚体衍生物。 还公开了制备杯芳烃和二聚体的方法。