专利检索 ap:("Graham TIMMINS" OR "Sharon Masters" OR "Vojo P. Deretic" OR "William Bishai") AND inv:"William Bishai" 第 1 页

1.

发明申请
RATIONALLY IMPROVED ISONIAZID AND ETHIONAMIDE DERIVATIVES AND ACTIVITY THROUGH SELECTIVE ISOTOPIC SUBSTITUTION 有权
标题翻译：通过选择性同位素替代方法改善异星体和酰胺衍生物和活性

公开(公告)号：US20130150415A1

公开(公告)日：2013-06-13

申请号：US13760605

申请日：2013-02-06

申请人： Graham TIMMINS , Sharon Masters , Vojo P. Deretic , William Bishai

发明人： Graham TIMMINS , Sharon Masters , Vojo P. Deretic , William Bishai

IPC分类号： C07D213/81

CPC分类号： C07D213/81 , A61K9/0019 , A61K9/0073 , A61K31/44 , A61K31/4409 , C07D213/83 , C07D213/86

摘要： The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

摘要翻译： 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。

2.

发明申请
RATIONALLY IMPROVED ISONIAZID AND ETHIONAMIDE DERIVATIVES AND ACTIVITY THROUGH SELECTIVE ISOTOPIC SUBSTITUTION 有权
标题翻译：通过选择性同位素替代方法改善异星体和酰胺衍生物和活性

公开(公告)号：US20110218220A1

公开(公告)日：2011-09-08

申请号：US12674188

申请日：2008-08-20

申请人： Graham Timmins , Sharon Master , Vojo P. Deretic , William Bishai

发明人： Graham Timmins , Sharon Master , Vojo P. Deretic , William Bishai

IPC分类号： A61K31/4409 , C07D213/83 , C07D213/81 , C07D213/86 , A61P31/06

CPC分类号： C07D213/81 , A61K9/0019 , A61K9/0073 , A61K31/44 , A61K31/4409 , C07D213/83 , C07D213/86

摘要： The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

摘要翻译： 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。

3.

发明申请
Hollow fiber technique for in vivo study of cell populations 审中-公开
标题翻译：中空纤维技术用于体内研究细胞群体

公开(公告)号：US20060182685A1

公开(公告)日：2006-08-17

申请号：US11221294

申请日：2005-09-06

申请人： William Bishai , Petros Karakousis

发明人： William Bishai , Petros Karakousis

IPC分类号： A61K49/00 , C12Q1/00

CPC分类号： G01N33/5088 , A61K47/6953 , C12Q1/02

摘要： The present invention relates to a method of using hollow fibers to evaluate cellular changes in vivo. A method for evaluating cellular changes in vivo in response to administration of a drug or drugs of interest is provided. The hollow fiber technique is also used to evaluate cellular changes in a microorganism in vivo. The technique is further used to evaluate cellular changes in a microorganism in vivo in response to administration of a drug or drugs of interest. A vaccine and method of vaccination are also provided.

摘要翻译： 本发明涉及一种使用中空纤维来评价体内细胞变化的方法。提供了一种用于评估响应于目标药物或药物的体内细胞变化的方法。中空纤维技术也用于评估体内微生物的细胞变化。该技术进一步用于响应于药物或目的药物的给药而在体内评估微生物中的细胞变化。还提供疫苗和疫苗接种方法。