公开(公告)号：US20180110864A1

公开(公告)日：2018-04-26

申请号：US15842684

申请日：2017-12-14

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey R. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D513/04 ,  C07D495/04 ,  C07D403/06 ,  C07C69/73

CPC classification number: A61K47/59 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K47/55 ,  A61K47/593 ,  A61K47/60 ,  C07C69/73 ,  C07C2601/08 ,  C07D403/06 ,  C07D495/04 ,  C07D513/04 ,  H05K999/99

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US20180064823A1

公开(公告)日：2018-03-08

申请号：US15782749

申请日：2017-10-12

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D513/04 ,  C07D495/04 ,  C07D403/06 ,  C07C69/73

CPC classification number: A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K47/55 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  C07C69/73 ,  C07C2601/08 ,  C07D403/06 ,  C07D495/04 ,  C07D513/04 ,  H05K999/99

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US11548861B2

公开(公告)日：2023-01-10

申请号：US16578003

申请日：2019-09-20

Applicant: Graybug Vision, Inc.

Inventor： Ming Yang ,  John G. Bauman ,  Jeffrey L. Cleland ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D271/04 ,  C07D231/12 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

公开(公告)号：US10111964B2

公开(公告)日：2018-10-30

申请号：US15842712

申请日：2017-12-14

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: A61K47/60 ,  A61K47/54 ,  A61K47/48 ,  C07D495/04 ,  C07D513/04 ,  C07C69/73 ,  C07D403/06 ,  A61K47/55 ,  A61K47/59

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US09956302B2

公开(公告)日：2018-05-01

申请号：US15782755

申请日：2017-10-12

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D403/06 ,  A61K47/54 ,  A61K47/59 ,  A61K47/55 ,  A61K47/60 ,  C07D513/04 ,  C07D495/04 ,  C07C69/73

CPC classification number: A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K47/55 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  C07C69/73 ,  C07C2601/08 ,  C07D403/06 ,  C07D495/04 ,  C07D513/04

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US20190060474A1

公开(公告)日：2019-02-28

申请号：US16162158

申请日：2018-10-16

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: A61K47/59 ,  C07D513/04 ,  C07D495/04 ,  C07D403/06 ,  C07C69/73 ,  A61K47/60 ,  A61K47/54 ,  A61K47/55

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US10159747B2

公开(公告)日：2018-12-25

申请号：US15842684

申请日：2017-12-14

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D513/04 ,  A61K47/54 ,  C07D495/04 ,  C07C69/73 ,  C07D403/06 ,  A61K47/60 ,  A61K47/55 ,  A61K47/59

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US10098965B2

公开(公告)日：2018-10-16

申请号：US15782744

申请日：2017-10-12

Applicant: Graybug Vision,Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: C07D403/06 ,  A61K47/54 ,  A61K47/59 ,  A61K47/55 ,  C07D513/04 ,  C07D495/04 ,  C07C69/73 ,  A61K47/60

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

公开(公告)号：US20210214374A1

公开(公告)日：2021-07-15

申请号：US17212873

申请日：2021-03-25

Applicant: Graybug Vision, Inc.

Inventor： John G. Bauman ,  Ming Yang ,  Nu Hoang ,  Emmett Cunningham ,  Jeffrey L. Cleland

IPC: C07D513/04 ,  C07D495/04 ,  A61K9/50 ,  C07D403/06

Abstract: The present invention provides new prodrugs of Sunitinib, Brinzolamide, and Dorzolamide and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

公开(公告)号：US10117950B2

公开(公告)日：2018-11-06

申请号：US15782749

申请日：2017-10-12

Applicant: Graybug Vision, Inc.

Inventor： Jeffrey L. Cleland ,  Ming Yang ,  John G. Bauman ,  Nu Hoang ,  Emmett Cunningham

IPC: A61K47/48 ,  A61K47/59 ,  C07D403/06 ,  C07D495/04 ,  C07C69/73 ,  C07D513/04 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.