公开(公告)号：US20160130238A1

公开(公告)日：2016-05-12

申请号：US14890731

申请日：2013-08-02

Applicant: Gregory ROSOCHA

Inventor： Gregory ROSOCHA ,  Robert BATEY

IPC: C07D257/04 ,  B01J19/24

CPC classification number: C07D257/04 ,  A61K31/41 ,  B01J19/24 ,  B01J2219/00164 ,  B01J2219/00166 ,  B01J2219/2401

Abstract: A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical process can form thiotetrazoles such as 2-((1-(naphthalen-1-yl)-1H-tetrazol-5-yl) thio)-N-(2-nitrophenyl)actetamide that is, a potent NNRTI with nanomolar activity.

Abstract translation: 可形成药物上可接受的药物NNRTI用于从噻唑三唑化合物开始治疗HIV的化学过程。 化学过程可以形成四唑，如2 - （（1-（萘-1-基）-1H-四唑-5-基）硫代）-N-（2-硝基苯基）actetamide，即具有纳摩尔活性的有效NNRTI 。