公开(公告)号：US20150284332A1

公开(公告)日：2015-10-08

申请号：US14437655

申请日：2012-10-24

Applicant: Gregory ROSOCHA

Inventor： Gregory Rosocha ,  Robert A. Batey

IPC: C07D217/02

CPC classification number: C07D217/02 ,  C07D217/04

Abstract: A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.

Abstract translation: 描述了从2-甲基-1-苯基取代的茚合成四氢异喹啉的方法。 该方法涉及使用四氧化锇来切割形成酮醛产物的茚双键，然后将其与形成取代的异喹啉的取代胺组合。 异喹啉可用作化学，农业化学，石油和天然气工业中的工业产品，也可用作制药工业中的药物。