公开(公告)号：US5962274A

公开(公告)日：1999-10-05

申请号：US41987

申请日：1998-03-13

Applicant: Griffith D. Parks

Inventor： Griffith D. Parks

IPC: C07K14/21 ,  C07K16/32 ,  C12N9/12 ,  C12N9/24 ,  C12P19/34 ,  C07H21/04

CPC classification number: C12N9/1211 ,  C07K14/21 ,  C07K16/32 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02

Abstract: Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention are designed so that the HN protein that binds to sialic acid is not expressed, and in certain embodiments a foreign membrane bound protein is expressed on the viral surface that targets the virus to particular cells or tissues. The vector then is able to deliver a toxin or cytotoxic agent to the target cell. Also disclosed are nucleic acid segments useful as viral genomes and methods of producing viral vectors.

Abstract translation: 公开了包含衍生自副粘病毒，猿猴病毒5（SV5））的病毒载体的组合物。 本发明的SV5载体被设计成使得结合唾液酸的HN蛋白质不被表达，并且在某些实施方案中，外源膜结合的蛋白质在靶向病毒的特定细胞或组织的病毒表面上表达。 然后载体能够将毒素或细胞毒性剂递送至靶细胞。 还公开了可用作病毒基因组的核酸区段和产生病毒载体的方法。