公开(公告)号：US20220062402A1

公开(公告)日：2022-03-03

申请号：US17416271

申请日：2019-12-20

Applicant: Griffith University

Inventor： Freda E.-C. JEN ,  Kate SEIB ,  Evgeny SEMCHENKO ,  Michael JENNINGS

IPC: A61K39/095 ,  C12N15/86

Abstract: This invention relates generally to polynucleotides, polypeptides, compositions, methods and uses for eliciting an immune response to Neisseria, methods for immunizing a subject against a Neisseria infection, and methods for preventing and/or treating a Neisseria infection in a subject. More particularly, the invention relates to antigenic Neisseria polypeptides and encoding polynucleotides, and related uses and methods, including use for preparing compositions and medicaments for eliciting an immune response to Neisseria, for immunizing a subject against a Neisseria infection, and for preventing and/or treating a Neisseria infection in a subject. The invention also relates to methods for producing therapeutic anti-Neisseria antigen-binding molecules, and therapeutic uses of those antigen-binding molecules.

公开(公告)号：US20230181709A1

公开(公告)日：2023-06-15

申请号：US17779411

申请日：2020-11-20

Applicant: Griffith University

Inventor： Kate SEIB

IPC: A61K39/095 ,  A61P37/04

CPC classification number: A61K39/095 ,  A61P37/04 ,  A61K2039/55566

Abstract: This invention relates, inter alia, to an immunogenic fragment of a Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae (SEQ ID NO: 1) for the prevention and treatment of Neisseria gonorrhoeae or gonococcal- or meningococcal-associated diseases and conditions. In some embodiments, the immunogenic fragment corresponds to a C-terminal fragment of the protein (SEQ ID NO: 2).