公开(公告)号：US10202345B2

公开(公告)日：2019-02-12

申请号：US14799872

申请日：2015-07-15

申请人： Gruenenthal GmbH

发明人： Anita Wegert ,  Bert Nolte ,  Klaus Linz ,  Stephanie Harlfinger ,  Babette-Yvonne Koegel ,  Paul Ratcliffe ,  Fritz Theil ,  Olga Groeger ,  Birgit Braun

IPC分类号： C07D209/54 ,  C07D405/06 ,  C07D409/04 ,  C07D409/14 ,  C07D209/96

摘要： The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

公开(公告)号：US10214520B2

公开(公告)日：2019-02-26

申请号：US15326138

申请日：2015-07-14

申请人： Gruenenthal GmbH

发明人： Anita Wegert ,  Sven Kuehnert ,  Rene Michael Koenigs ,  Bert Nolte ,  Klaus Linz ,  Stephanie Harlfinger ,  Babette-Yvonne Koegel ,  Paul Ratcliffe ,  Fritz Theil ,  Olga Groeger ,  Birgit Braun

IPC分类号： C07D209/54 ,  C07D417/06 ,  C07D209/96 ,  A61K31/403 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  A61K31/541 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14

摘要： The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.