公开(公告)号：US20140329790A1

公开(公告)日：2014-11-06

申请号：US14332338

申请日：2014-07-15

申请人： Guangmei YAN ,  Haiyan HU ,  Tiandong LENG ,  Hanfei SANG ,  Jingxia ZHANG ,  Pengxin QIU ,  Shujia ZHOU ,  Jiesi CHEN ,  Xiuhua YOU

发明人： Guangmei YAN ,  Haiyan HU ,  Tiandong LENG ,  Hanfei SANG ,  Jingxia ZHANG ,  Pengxin QIU ,  Shujia ZHOU ,  Jiesi CHEN ,  Xiuhua YOU

IPC分类号： A61K31/568

CPC分类号： A61K31/568 ,  C07J1/0007

摘要： Disclosed is the use of 5α-androstane-3β,5,6β-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

摘要翻译： 公开了在制备神经保护药物中使用5α-雄甾烷-3＆bgr，5,6和bri-三醇。 该化合物对脑缺血，脊髓缺血或缺氧引起的神经元损伤具有显着的保护作用，并且在其有效剂量范围内无明显的毒性反应。

公开(公告)号：US20160051685A1

公开(公告)日：2016-02-25

申请号：US14839869

申请日：2015-08-28

申请人： Guangmei Yan ,  Haiyan HU ,  Jingxia ZHANG ,  Pengxin QIU ,  Ling LI ,  Ning TIAN

发明人： Guangmei Yan ,  Haiyan HU ,  Jingxia ZHANG ,  Pengxin QIU ,  Ling LI ,  Ning TIAN

IPC分类号： A61K47/40 ,  A61K9/00 ,  A61K31/568

CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/565 ,  A61K31/568 ,  A61K47/6951 ,  B82Y5/00

摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection. Drying the filtrate yields a solid for injection.

摘要翻译： 公开了5α-雄甾烷-3＆bgr，5,6和三烯注射剂及其制备。 注射剂使用羟丙基 - 环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精一起存在。 注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。 制备方法包括将羟丙基 - 环糊精溶液，5α-雄甾烷-3β，5,6α-三醇和至少一种额外的可溶性赋形剂在水中依次溶解，得到原始注射液， 注射溶液脱色，去热原，过滤和灭菌获得注射。 干燥滤液得到固体，用于注射。