公开(公告)号：US20130281730A1

公开(公告)日：2013-10-24

申请号：US13997303

申请日：2011-10-20

申请人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

发明人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

IPC分类号： C07C229/64

CPC分类号： C07C229/64 ,  C07C227/20 ,  C07C231/12 ,  C07C233/54

摘要： Disclosed is a process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, characterized in that carbon dioxide is introduced into a system of p-acetaminophenol and a basic compound at a temperature of 150° C.˜220° C. and a pressure of 0.5˜5.0 MPa in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate, and the crude product 5-aminosalicylate is separated, and then acidified to prepare 5-aminosalicylic acid (5-ASA). Since the gas phase catalytic reaction replaces a solid phase thermo-chemical reaction, the reaction is significantly improved in terms of the process flow, reaction conditions, product quality and energy consumption. In addition, the reaction has a short reaction time, good selectivity, high yield and no formation of wastes during the reaction, and is suitable for industrial production.

摘要翻译： 公开了通过气相催化羧化制备5-氨基水杨酸的方法，其特征在于在150℃〜220℃的温度下将二氧化碳引入对乙酰氨基苯酚和碱性化合物的体系中， 在催化剂存在下为0.5〜5.0MPa，进行气相催化羧化反应以形成5-氨基水杨酸盐​​，并将5-氨基水杨酸粗产物分离，然后酸化以制备5-氨基水杨酸（ 5-ASA）。 由于气相催化反应代替了固相热化学反应，反应在工艺流程，反应条件，产品质量和能耗方面都得到了显着改善。 此外，反应时间短，选择性好，产率高，反应时不产生废物，适用于工业生产。

公开(公告)号：US09067867B2

公开(公告)日：2015-06-30

申请号：US13997303

申请日：2011-10-20

申请人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

发明人： Guangxing Li ,  Jinjin Li ,  Dajian Zhu ,  Qiang Jiang ,  Lingli Cai ,  Yong Xie ,  Lixin Gan

IPC分类号： C07C229/64 ,  C07C227/18 ,  C07C227/20 ,  C07C231/12

CPC分类号： C07C229/64 ,  C07C227/20 ,  C07C231/12 ,  C07C233/54

摘要： Disclosed is a process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, characterized in that carbon dioxide is introduced into a system of p-acetaminophenol and a basic compound at a temperature of 150° C.˜220° C. and a pressure of 0.5˜5.0 MPa in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate, and the crude product 5-aminosalicylate is separated, and then acidified to prepare 5-aminosalicylic acid (5-ASA). Since the gas phase catalytic reaction replaces a solid phase thermo-chemical reaction, the reaction is significantly improved in terms of the process flow, reaction conditions, product quality and energy consumption. In addition, the reaction has a short reaction time, good selectivity, high yield and no formation of wastes during the reaction, and is suitable for industrial production.

摘要翻译： 公开了一种通过气相催化羧化制备5-氨基水杨酸的方法，其特征在于在150℃〜220℃的温度下将二氧化碳引入对乙酰氨基苯酚和碱性化合物的体系中， 在催化剂存在下为0.5〜5.0MPa，进行气相催化羧化反应以形成5-氨基水杨酸酯，分离出粗产物5-氨基水杨酸酯，然后酸化以制备5-氨基水杨酸（ 5-ASA）。 由于气相催化反应代替了固相热化学反应，反应在工艺流程，反应条件，产品质量和能耗方面都得到了显着改善。 此外，反应时间短，选择性好，产率高，反应时不产生废物，适用于工业生产。