公开(公告)号：US20210292414A1

公开(公告)日：2021-09-23

申请号：US17118934

申请日：2020-12-11

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Jeffrey B. Stavenhagen ,  Søren Christensen ,  Jan Egebjerg ,  Tina Stummann ,  Arnout Gerritsen ,  Edward van den Brink ,  Paul Parren ,  Esben Trabjerg ,  Kasper Dyrberg Rand

IPC: C07K16/28

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders such as Alzheimers disease (AD).