公开(公告)号：US12258305B2

公开(公告)日：2025-03-25

申请号：US17869116

申请日：2022-07-20

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: A61P25/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  C07C235/06 ,  C07C235/08 ,  C07C235/26

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US20210032196A1

公开(公告)日：2021-02-04

申请号：US16943872

申请日：2020-07-30

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen ,  Anette Graven Sams ,  Krestian Larsen

IPC: C07C235/08 ,  C07C255/44

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US20240327336A1

公开(公告)日：2024-10-03

申请号：US18062246

申请日：2022-12-06

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen ,  Anette Graven Sams ,  Krestian Larsen

IPC: C07C235/08 ,  C07C255/44

CPC classification number: C07C235/08 ,  C07C255/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/16

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US11434199B2

公开(公告)日：2022-09-06

申请号：US16781106

申请日：2020-02-04

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: C07C235/06 ,  A61P25/08 ,  A61P25/06 ,  A61P25/04 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/18 ,  C07C235/08 ,  C07C235/26

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US20220380300A1

公开(公告)日：2022-12-01

申请号：US17869116

申请日：2022-07-20

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: C07C235/06 ,  A61P25/08 ,  A61P25/06 ,  A61P25/04 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/18 ,  C07C235/08 ,  C07C235/26

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US20200172474A1

公开(公告)日：2020-06-04

申请号：US16781106

申请日：2020-02-04

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: C07C235/06 ,  A61P25/18 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C235/26 ,  C07C235/08

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US20190256456A1

公开(公告)日：2019-08-22

申请号：US15899843

申请日：2018-02-20

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: C07C235/06 ,  A61P25/08 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/04

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US11548849B2

公开(公告)日：2023-01-10

申请号：US16943872

申请日：2020-07-30

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen ,  Anette Graven Sams ,  Krestian Larsen

IPC: C07C235/08 ,  C07C255/44

Abstract: The present invention provides novel compounds (e.g., compounds of Formula I) which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

公开(公告)号：US10590067B2

公开(公告)日：2020-03-17

申请号：US15899843

申请日：2018-02-20

Applicant: H. Lundbeck A/S

Inventor： Mario Rottlander ,  Anette Graven Sams ,  Xiaofang Wang ,  Debasis Das ,  Jian Hong ,  Shu Hui Chen

IPC: C07C235/06 ,  A61P25/08 ,  A61P25/06 ,  A61P25/04 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/18 ,  C07C235/08 ,  C07C235/26

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Exemplary compounds of the invention have the structure of Formula 1. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.