公开(公告)号：US11534435B2

公开(公告)日：2022-12-27

申请号：US17662351

申请日：2022-05-06

申请人： HAINAN POLY PHARM CO., LTD.

发明人： Youqing Shen ,  Quan Zhou ,  Changhuo Xu ,  Jiajia Xiang

IPC分类号： A61K47/58 ,  A61K31/4745 ,  C08F220/60 ,  C08F220/36 ,  C08F297/00

摘要： This present invention relates to a drug carrier comprising a polymer of γ-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal, and a method for preparing the same. It can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.