公开(公告)号：US20240059681A1

公开(公告)日：2024-02-22

申请号：US18369069

申请日：2023-09-15

Applicant: HAISCO PHARMACEUTICALS PTE. LTD.

Inventor： Yao Li ,  Zongjun Shi ,  Guobiao ZHANG ,  Lei Chen ,  Wenjing Wang ,  Xiaobo Zhang ,  Dengyu Zheng ,  Bo Xu ,  Xin Liu ,  Yajun Wang ,  Fei Ye ,  Pingming Tang ,  Jia Ni ,  Chen Zhang ,  Pangke Yan

IPC: C07D413/12 ,  C07D267/10 ,  C07D413/14 ,  C07D417/12 ,  C07F9/6527

CPC classification number: C07D413/12 ,  C07D267/10 ,  C07D413/14 ,  C07D417/12 ,  C07F9/6527

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

公开(公告)号：US11807635B2

公开(公告)日：2023-11-07

申请号：US17976291

申请日：2022-10-28

Applicant: HAISCO PHARMACEUTICALS PTE. LTD

Inventor： Yao Li ,  Zongjun Shi ,  Guobiao Zhang ,  Lei Chen ,  Wenjing Wang ,  Xiaobo Zhang ,  Dengyu Zheng ,  Bo Xu ,  Xin Liu ,  Yajun Wang ,  Fei Ye ,  Pingming Tang ,  Jia Ni ,  Chen Zhang ,  Pangke Yan

IPC: C07D413/12 ,  C07D267/10 ,  C07D413/14 ,  C07D417/12 ,  C07F9/6527

CPC classification number: C07D413/12 ,  C07D267/10 ,  C07D413/14 ,  C07D417/12 ,  C07F9/6527

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

公开(公告)号：US20230121807A1

公开(公告)日：2023-04-20

申请号：US17976291

申请日：2022-10-28

Applicant: HAISCO PHARMACEUTICALS PTE. LTD

Inventor： Yao Li ,  Zongjun Shi ,  Guobiao ZHANG ,  Lei Chen ,  Wenjing Wang ,  Xiaobo Zhang ,  Dengyu Zheng ,  Bo Xu ,  Xin Liu ,  Yajun Wang ,  Fei Ye ,  Pingming Tang ,  Jia Ni ,  Chen Zhang ,  Pangke Yan

IPC: C07D413/12 ,  C07D413/14 ,  C07D267/10 ,  C07D417/12 ,  C07F9/6527

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.