公开(公告)号：US10196396B2

公开(公告)日：2019-02-05

申请号：US15406556

申请日：2017-01-13

Applicant: HANDOK INC.

Inventor： Jin-Hwa Lee ,  Seung-Yong Kim ,  Do-Ran Kim ,  Koo-Hyeon Ahn ,  Gwi-Bin Lee ,  Doo-Seop Kim ,  Hyun-Sook Hwang

IPC: A01N43/04 ,  A61K31/70 ,  C07D487/04 ,  C07D519/00 ,  A61K31/7068 ,  A61K31/7064 ,  A61K31/706

Abstract: The present disclosure provides compounds useful in the amelioration, prevention or treatment of A3 adenosine receptor mediated diseases, such as glaucoma and glaucoma-related ocular disorders, having the structure of Formula I as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for ameliorating, preventing or treating A3 adenosine receptor mediated diseases using the compound.

公开(公告)号：US20170204101A1

公开(公告)日：2017-07-20

申请号：US15406556

申请日：2017-01-13

Applicant: HANDOK INC.

Inventor： Jin-Hwa Lee ,  Seung-Yong Kim ,  Do-Ran Kim ,  Koo-Hyeon Ahn ,  Gwi-Bin Lee ,  Doo-Seop Kim ,  Hyun-Sook Hwang

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  C07D519/00

Abstract: The present disclosure provides compounds useful in the amelioration, prevention or treatment of A3 adenosine receptor mediated diseases, such as glaucoma and glaucoma-related ocular disorders, having the structure of Formula I as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for ameliorating, preventing or treating A3 adenosine receptor mediated diseases using the compound.