公开(公告)号：US20240360150A1

公开(公告)日：2024-10-31

申请号：US18683619

申请日：2022-08-22

Applicant: HANGZHOU GLUBIO PHARMACEUTICAL CO. LTD.

Inventor： Liqiang FU ,  Linglong KONG ,  Lei ZHANG ,  Gang LU ,  Yifeng XIA ,  Chin-Chun LU ,  Christine SURKA

IPC: C07D498/04 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  C07D401/04 ,  C07D401/14 ,  C07D491/107 ,  C07D498/14

CPC classification number: C07D498/04 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  C07D401/04 ,  C07D401/14 ,  C07D491/107 ,  C07D498/14

Abstract: An isoindolinone compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of proliferative diseases. A pharmaceutical composition contains the compound or the salt thereof and a pharmaceutically acceptable carrier.

公开(公告)号：US20240294500A1

公开(公告)日：2024-09-05

申请号：US18568744

申请日：2022-06-06

Applicant: HANGZHOU GLUBIO PHARMACEUTICAL CO., LTD.

Inventor： Liqiang FU ,  Linglong KONG ,  Yifeng XIA

IPC: C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14

CPC classification number: C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14

Abstract: Isoindolinone compounds represented by the structural formula (I) or pharmaceutically-acceptable salts thereof can be used for the treatment of a proliferative disorder. Pharmaceutical compositions contain the isoindolinone compound or a salt thereof, and a pharmaceutically acceptable carrier.

公开(公告)号：US20250049798A1

公开(公告)日：2025-02-13

申请号：US18708498

申请日：2022-11-08

Applicant: HANGZHOU GLUBIO PHARMACEUTICAL CO. LTD.

Inventor： Liqiang FU ,  Linglong KONG ,  Gang LU ,  Yifeng XIA ,  Chin-Chun LU

IPC: A61K31/519 ,  A61P35/00 ,  C07D487/04 ,  C07D487/14

Abstract: A compound for degrading a Wee1 protein kinase or a pharmaceutically acceptable salt thereof, and the use thereof in the treatment of proliferative diseases.