公开(公告)号：US20220202795A1

公开(公告)日：2022-06-30

申请号：US17600639

申请日：2020-04-01

申请人： HANMI PHARM. CO., LTD

发明人： Hyuk Jun CHO ,  Taek KWON ,  Ho Taek IM ,  Yong ll KIM ,  Jin A JUNG ,  Han Kil SON ,  Sung Hee HONG

IPC分类号： A61K31/4439 ,  A61K9/28

摘要： The present disclosure relates to a pharmaceutical composition containing esomeprazole or a pharmaceutically acceptable salt thereof and with a dual release profile, and particularly to a pharmaceutical composition which exhibits a dual release profile of immediate release and sustained release so that long-term efficacy can be sustained. The pharmaceutical composition containing esomeprazole or a pharmaceutically acceptable salt thereof and with a dual release profile, according to the present disclosure, can secure bioavailability equivalent to that of existing esomeprazole immediate-release/enteric-release formulations, and can maintain long-term efficacy due to the dual release profile thereof even when administered once a day, thus preventing the occurrence of nocturnal acid breakthrough, and accordingly, can be effectively used as a therapeutic agent for nocturnal acid breakthrough.