公开(公告)号：US20200048185A1

公开(公告)日：2020-02-13

申请号：US16537324

申请日：2019-08-09

申请人： HARMAN FINOCHEM LIMITED

发明人： Vijay Trimbak KADAM ,  Nareesh SARANAPU ,  Amin Rashid SHAIKH ,  Harpreet Singh MINHAS ,  Gurpreet Singh MINHAS

IPC分类号： C07C213/04

摘要： The present invention, discloses optically pure compounds of l-Norepinephrine and its acid addition salts and hydrates and process for the preparation thereof. Specifically, the present invention discloses optically pure compounds of l-Norepinephrine bitartrate, its process of preparation and pharmaceutical compositions comprising the same.

公开(公告)号：US20230057675A1

公开(公告)日：2023-02-23

申请号：US17782048

申请日：2020-11-28

申请人： HARMAN FINOCHEM LIMITED

发明人： Nitin Sharadchandra PRADHAN ,  Vijay Trimbak KADAM ,  Vishalkumar Rajendrakumar SHAH ,  Pankaj Shrawan CHAUDHARI ,  Harpreet Singh MINHAS ,  Gurpreet Singh MINHAS

IPC分类号： C07D257/04 ,  G01N30/02

摘要： Disclosed herein is a process for the preparation and purification of Valsartan. The process according to the invention is capable of removing the toxic nitroamine impurities and providing substantially pure Valsartan.

公开(公告)号：US20220009888A1

公开(公告)日：2022-01-13

申请号：US17291736

申请日：2019-11-06

申请人： HARMAN FINOCHEM LIMITED

发明人： Vijay Trimbak KADAM ,  Dhananjay U ddhavrao ED AKI ,  Ravin-dra Bhausaheb PAGIRE ,  Mayur Sanjay KULKA-RNI ,  Harpreet Singh MINHAS ,  Gurpreet Singh MINHAS

IPC分类号： C07D207/12 ,  C07C303/32 ,  C07C303/44

摘要： Disclosed herein is an efficacious process for preparation of highly purified Glycopyrrolate tosylate in high yield. The process is being cost effective, environment friendly and easily scalable to high volume industrial production.

公开(公告)号：US20210371381A1

公开(公告)日：2021-12-02

申请号：US16319175

申请日：2017-07-17

申请人： HARMAN FINOCHEM LIMITED

发明人： Vijay Trimbak KADAM ,  Nareesh SARANAPU ,  Santosh Uttamrao CHAVAN ,  Harpreet Singh MINHAS ,  Gurpreet Singh MINHAS

IPC分类号： C07D211/34

摘要： Disclosed herein a process for the preparation of highly pure dexmethylphenidate hydrochloride (Formula-I) which comprises the steps of neutralization of dl-threomethylphenidate hydrochloride to dl-threo methylphenidate; subsequent resolution of dl-threo methylphenidate using amino acid or its derivatives as chiral resolution agent to yield dexmethylphenidate salt; hydrolysis of the salt and further conversion of dexmethylphenidate into its hydrochloride salt.

公开(公告)号：US20170349534A1

公开(公告)日：2017-12-07

申请号：US15539085

申请日：2015-04-30

申请人： HARMAN FINOCHEM LIMITED

发明人： Vijay Trimbak KADAM ,  Dhananjay Uddavrao EDAKI ,  Nagaraju ORUGANTI

IPC分类号： C07C221/00 ,  C07C225/16

CPC分类号： C07C221/00 ,  C07B2200/07 ,  C07C225/16 ,  C07C311/19

摘要： The present invention discloses an improved process for preparing pure (6R)-6-(dimethylamino)-4,4-diphenyl-3-heptanone and its hydrochloride salt.