公开(公告)号：US20210371383A1

公开(公告)日：2021-12-02

申请号：US16979503

申请日：2019-03-12

Applicant: HAWAII BIOTECH, INC.

Inventor： Guan-Sheng JIAO ,  Seong Jin KIM ,  Alan T. JOHNSON

IPC: C07D213/65 ,  C07D213/61 ,  C07D213/54

Abstract: Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2′ are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.