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17 条记录 (耗时 0.02 秒)

    MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    1.
    发明申请
    MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF 有权

    公开(公告)号：US20210070826A1

    公开(公告)日：2021-03-11

    申请号：US16952861

    申请日：2020-11-19

    申请人： HCW Biologics, Inc.

    发明人： Hing Wong

    IPC分类号： C07K14/54 ,  C07K14/71 ,  C07K14/715 ,  C07K14/745 ,  C07K16/28

    摘要： Provided herein are multi-chain chimeric polypeptides that include:
    (a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.

    SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    4.
    发明申请
    SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF 有权

    公开(公告)号：US20230039157A1

    公开(公告)日：2023-02-09

    申请号：US17870373

    申请日：2022-07-21

    申请人： HCW Biologics, Inc.

    发明人： Hing Wong

    IPC分类号： C07K16/18 ,  A61P3/10 ,  C07K16/28 ,  C12N5/0783

    摘要： Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble tissue factor domain; and (iii) a second target-binding domain. Also provided here are methods of using these single-chain chimeric polypeptides and nucleic acids encoding these single-chain chimeric polypeptides.

    METHODS OF TREATING AGING-RELATED DISORDERS
    5.
    发明申请
    METHODS OF TREATING AGING-RELATED DISORDERS 有权

    公开(公告)号：US20210060064A1

    公开(公告)日：2021-03-04

    申请号：US16557875

    申请日：2019-08-30

    申请人： HCW Biologics, Inc.

    发明人： Hing Wong

    IPC分类号： A61K35/17 ,  C07K14/715 ,  C07K14/705

    摘要： Provided herein are methods of treating an aging-related disease or condition in a subject in need thereof, killing or reducing the number of senescent cells in a subject in need thereof, improving the texture and/or appearance of skin and/or hair in a subject in need thereof, and assisting in the treatment of obesity in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more natural killer (NK) cell activating agent(s) and/or a therapeutically effective number of activated NK cells.

    SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    8.
    发明申请
    SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF 有权

    公开(公告)号：US20230023389A1

    公开(公告)日：2023-01-26

    申请号：US17871211

    申请日：2022-07-22

    申请人： HCW Biologics, Inc.

    发明人： Hing Wong

    IPC分类号： C07K16/18 ,  A61P3/10 ,  C07K16/28 ,  C12N5/0783

    摘要： Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble tissue factor domain; and (iii) a second target-binding domain. Also provided here are methods of using these single-chain chimeric polypeptides and nucleic acids encoding these single-chain chimeric polypeptides.

    SINGLE-CHAIN AND MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    9.
    发明申请
    SINGLE-CHAIN AND MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF 有权

    公开(公告)号：US20210100840A1

    公开(公告)日：2021-04-08

    申请号：US16557822

    申请日：2019-08-30

    申请人： HCW Biologics, Inc.

    发明人： Hing Wong

    IPC分类号： A61K35/17 ,  C07K16/24 ,  C07K16/28 ,  C07K16/22 ,  C07K16/46

    摘要： The present disclosure relates to the field of biotechnology, and more specifically, to single-chain and multi-chain chimeric polypeptides having a linker domain positioned between two target-binding domains that are useful for a variety of applications including, without limitation, stimulating an immune cell, inducing or increasing proliferation of an immune cell, inducing differentiation of an immune cell, or treating a subject in need thereof (e.g., a subject having cancer or an aging-related disease or condition).